ArticleNature communications2024
The Arabidopsis receptor-like kinase WAKL4 limits cadmium uptake via phosphorylation and degradation of NRAMP1 transporter.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Knocking out a wall-associated kinase gene enhances rice resistance to planthoppers in the field.Pest management science · 2026Article
- Molecular Evolution and Mechanisms of Plants NRAMP Transporters in Response to Heavy Metal Stress.Plants (Basel, Switzerland) · 2026Review
- Wall-associated kinase-like4 regulates plant salt tolerance by maintaining cell wall pectin homeostasis and cellular redox homeostasis in Arabidopsis.Plant molecular biology · 2026Article
- Pyramiding elite alleles of the genetically linked OsNRAMP5 and OsHMA3 confers low Cd accumulation in rice grains without compromising stress tolerance.Plant communications · 2026Article
- Harnessing Antioxidants for Abiotic Stress Management: Mechanistic Insights and Prospects for Sustainable Agriculture.Antioxidants (Basel, Switzerland) · 2026Review
- Lobularia maritima essential oil modulates heavy-metal transporter expression and mitigates cadmium stress in durum wheat.Protoplasma · 2026Article
- Functional characterization of SmNRAMP1 allelic variants conferring reduced cadmium uptake in Salvia miltiorrhiza.BMC plant biology · 2026Article
- Rapid acquisition of ionomic and morphological data from plant seeds through fast X-ray fluorescence microscopy and computer vision.Plant phenomics (Washington, D.C.) · 2025Article
- The apple phosphate starvation response transcription factor MdPHR1 positively regulates zinc and cadmium tolerance.Plant cell reports · 2025Article
- The MATE family transporter CaDTX12 confers cadmium accumulation in pepper (Capsicum annuum L.).Functional & integrative genomics · 2025Article
- Genome-wide association study of common bean (Phaseolus vulgaris L.) unveils novel loci governing root-to-seed zinc allocation.Scientific reports · 2025Article
- Characterization of Cd and As accumulation and subcellular distribution in different varieties of perennial ryegrasses.BMC plant biology · 2025Article
- A cell wall-associated kinase phosphorylates NLR immune receptor to negatively regulate resistosome formation.Nature plants · 2025Article
- Function of WAKs in Regulating Cell Wall Development and Responses to Abiotic Stress.Plants (Basel, Switzerland) · 2025Review
- Identification and functional analysis ofFrontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Cadmium (Cd) is a detrimental heavy metal propagated from soil to the food chain via plants, posing a great risk to human health upon consumption. Despite the understanding of Cd tolerance mechanisms in plants, whether and how plants actively respond to Cd and in turn restrict its uptake and accumulation remain elusive. Here, we identify a cell wall-associated receptor-like kinase 4 (WAKL4) involved in specific tolerance to Cd stress. We show that Cd rapidly and exclusively induces WAKL4 accumulation by promoting WAKL4 transcription and blocking its vacuole-dependent proteolysis in roots. The accumulated WAKL4 next interacts with and phosphorylates the Cd transporter NRAMP1 at Tyr488, leading to the enhanced ubiquitination and vacuole-dependent degradation of NRAMP1, and consequently reducing Cd uptake. Our findings therefore uncover a mechanism conferred by the WAKL4-NRAMP1 module that enables plants to actively respond to Cd and limit its uptake, informing the future molecular breeding of low Cd accumulated crops or vegetables.
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