Evidence map›Paper›PMID 39497519›Full record

ArticleEmerging microbes & infections2024

COVID-19 vaccination modified the effect of nirmatrelvir-ritonavir on post-acute mortality and rehospitalization: a retrospective cohort study.

Huwen Wang, Yuchen Wei, Guozhang Lin, Christopher Boyer, Katherine Min Jia, Chi Tim Hung, Xiaoting Jiang, Conglu Li, Carrie Ho Kwan Yam, Tsz Yu Chow and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Huwen WangSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Yuchen WeiSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Guozhang LinSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Christopher BoyerCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Katherine Min JiaCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Chi Tim HungSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Xiaoting JiangSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Conglu LiSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Carrie Ho Kwan YamSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Tsz Yu ChowSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Yawen WangDivision of Landscape Architecture, Department of Architecture, Faculty of Architecture, The University of Hong Kong, Hong Kong, China.
Shi ZhaoSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Zihao GuoSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Kehang LiSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Aimin YangDepartment of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Chris Ka Pun MokLi Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
David S C HuiS.H. Ho Research Centre for Infectious Diseases, Chinese University of Hong Kong, Hong Kong, China.
Ka Chun ChongSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0001-5610-1298
Eng Kiong YeohSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction or its impact on post-acute outcomes. This study examined the interaction between nirmatrelvir-ritonavir and complete COVID-19 vaccination on reducing the risk of post-acute outcomes among COVID-19 patients. We followed COVID-19 patients hospitalized between 11 March 2022 and 10 October 2023, until 31 October 2023 in Hong Kong. Exposure groups were based on nirmatrelvir-ritonavir usage and vaccination status (fully or not fully vaccinated). Post-acute death and all-cause rehospitalization were the study outcomes. Propensity score weighting was applied to balance covariates among exposure groups, including age, sex, Charlson Comorbidity Index, and concomitant treatments. Multiplicative and additive interactions between nirmatrelvir-ritonavir and vaccination status were assessed. A total of 50,438 COVID-19 patients were included in this study and arranged into four exposure groups. Significant additive interaction on post-acute rehospitalization was observed (relative excess risk, 0.10; 95% CI, 0.02-0.19;

Indexed as

Antiviral AgentsCOVID-19RitonavirSARS-CoV-2AdultAgedAged, 80 and overCOVID-19 VaccinesDrug CombinationsFemaleHong KongHospitalizationHumansLopinavirMaleMiddle AgedAntiviral AgentsCOVID-19 VaccinesDrug CombinationsLopinavirRitonavirantiviralinteractionlong covidPaxlovidpost-covid

Identifiers

PMID39497519
PMCPMC11539398

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.