Evidence map›Paper›PMID 39497631›Full record

ArticleObesity (Silver Spring, Md.)2024

The association of higher offspring early-childhood weight gain with prepregnancy metabolic and bariatric surgery.

Maya-Jean Hilaire, Annelise Babcock, Glenn White, Cynthia F Masson, Rany M Salem, Uma M Reddy, Dympna Gallagher, Charles A LeDuc, Vidhu V Thaker

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maya-Jean HilaireColumbia College, Columbia University in the City of New York, New York, New York, USA.
Annelise BabcockDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
Glenn WhiteDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
Cynthia F MassonDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Rany M SalemHerbert Wertheim School of Public Health and Human Longevity Science, University of California at San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0001-8816-6862
Uma M ReddyDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Dympna GallagherDepartment of Medicine, Columbia University Irving Medical Center, New York, New York, USA.ORCID https://orcid.org/0000-0003-1769-9754
Charles A LeDucDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-2073-5050
Vidhu V ThakerDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-3537-2782

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1TR001873NIDDK NIH HHS P30 DK026687NIH National Institute of Diabetes and Digestive and Kidney Diseases P30DK26687
6 · The paper itself

Abstract

objectiveThe objective of this study was to assess maternal gestational outcomes and offspring growth trajectories following prepregnancy metabolic and bariatric surgery (MBS) compared with non-MBS controls.

methodsSingle-center deliveries between January 2020 and March 2023 with prepregnancy Roux-en-Y gastric bypass (herein referred to as "bypass"), sleeve gastrectomy (herein referred to as "sleeve"), and non-MBS controls were included. Offspring growth trajectories were compared with the World Health Organization child growth standards. Linear mixed models assessed MBS-bypass and MBS-sleeve offspring weight, length, and BMI trajectories with a prepregnancy BMI 27 to 37 kg/m

resultsThe study included 440 participants with prepregnancy MBS (MBS-bypass, 185; MBS-sleeve, 225; 76% Hispanic/Latino) and 13,434 non-MBS controls. Gestational weight gain and gestational diabetes mellitus were similar, whereas hypertensive disorders of pregnancy were more common after MBS. The post-MBS offspring had lower birth weight but higher weight gain at 24 months (sleeve, +1.4 kg [95% CI: 1.0-1.9]; bypass, +0.5-0.7 kg [95% CI: 0.0-1.2]) compared with non-MBS groups. Male children had higher weight gain than females. The post-MBS-sleeve but not the post-MBS-bypass offspring had higher BMI z scores.

conclusionsThe higher early-life weight gain and sex differences in the post-MBS-sleeve group compared with the post-MBS-bypass group provide a window toward elucidating pathways to mitigate intergenerational metabolic risk transfer.

Indexed as

Bariatric SurgeryWeight GainAdultBirth WeightBody Mass IndexChild, PreschoolFemaleGastric BypassGestational Weight GainHumansInfantInfant, NewbornMalePediatric ObesityPregnancyPregnancy Complications

Identifiers

PMID39497631
PMCPMC11694145

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.