Evidence map›Paper›PMID 39497922›Full record

ArticleFrontiers in cellular neuroscience2024

Somatostatin interneuron fate-mapping and structure in a Pten knockout model of epilepsy.

Austin W Drake, Lilian G Jerow, Justin V Ruksenas, Carlie McCoy, Steve C Danzer

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Austin W DrakeDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Lilian G JerowDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Justin V RuksenasDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Carlie McCoyDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Steve C DanzerDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Funding

Selective disruption of hippocampal dentate granule cells in autism: impact of PTR01NS065020 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2023
$6.1M
Anti-epileptogenic role of mTOR activation among hippocampal interneuronsR01NS121042 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2022 to 2025
$2.0M
Regulation of Epileptogenesis by Hippocampal Somatostatin Interneurons in a Model of mTORopathiesF31NS136029 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DRAKE, AUSTIN · 2024 to 2024
$43k
NINDS NIH HHS F31 NS136029NINDS NIH HHS R01 NS065020NINDS NIH HHS R01 NS121042
6 · The paper itself

Abstract

Disruption of inhibitory interneurons is common in the epileptic brain and is hypothesized to play a pivotal role in epileptogenesis. Abrupt disruption and loss of interneurons is well-characterized in status epilepticus models of epilepsy, however, status epilepticus is a relatively rare cause of epilepsy in humans. How interneuron disruption evolves in other forms of epilepsy is less clear. Here, we explored how somatostatin (SST) interneuron disruption evolves in quadruple transgenic Gli1-CreER

Indexed as

epilepsymammalian target of rapamycin (mTOR)morphologymTORopathiesphosphatase and tensin homolog (Pten)somatostatin interneuronstransgenic mice

Identifiers

PMID39497922
PMCPMC11532043

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.