Evidence map›Paper›PMID 39498574›Full record

Trial reportEuropean journal of heart failure2025

Long-term clinical outcomes and healthcare resource utilization in male and female patients following hospitalization for heart failure.

Tauben Averbuch, Shun Fu Lee, Brandon Zagorski, Ambarish Pandey, Mark C Petrie, Tor Biering-Sorensen, Feng Xie, Harriette G C Van Spall

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02112227 (Patient-centered Care Transitions in Heart Failure), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02112227 nacompletednot on this map

Patient-centered Care Transitions in Heart Failure: A Pragmatic Cluster

TypeinterventionalSponsorPopulation Health Research InstituteRan2015 to 2016Enrolled3,500ConditionsHeart FailureArmsPACT-HF Model
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tauben AverbuchDepartment of Cardiology, University of Calgary, Calgary, AB, Canada.
Shun Fu LeePopulation Health Research Institute, Hamilton, ON, Canada.
Brandon ZagorskiInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Ambarish PandeyDepartment of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mark C PetrieSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Tor Biering-SorensenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Feng XieCentre for Health Economics and Policy Analysis, McMaster University, Hamilton, ON, Canada.
Harriette G C Van SpallPopulation Health Research Institute, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0002-8370-4569

Funding

CIHR 135917Ontario Ministry of Health and Long-Term Care 6686
6 · The paper itself

Abstract

aimsHeart failure (HF) is a leading cause of hospitalization, and sex differences in care have been described. We assessed sex-specific clinical outcomes and healthcare resource utilization following hospitalization for HF. METHODS AND

resultsThis was an exploratory analysis of patients hospitalized for HF across 10 Canadian hospitals in the Patient-Centered Care Transitions in HF (PACT-HF) cluster-randomized trial. The primary outcome was all-cause mortality. Secondary outcomes included all-cause readmissions, HF readmissions, emergency department (ED) visits, and healthcare resource utilization. Outcomes were obtained via linkages with administrative datasets. Among 4441 patients discharged alive, 50.7% were female. By 5 years, 63.6% and 65.5% of male and female patients, respectively, had died (p = 0.19); 85.4% and 84.4%, respectively, were readmitted (p = 0.35); and 72.2% and 70.9%, respectively, received ED care without hospitalization (p = 0.34). There were no sex differences in mean [SD] number of all-cause readmissions (males, 2.8 [7.8] and females, 3.0 [8.4], p = 0.54), HF readmissions (males, 0.9 [3.6] and females, 0.9 [4.5], p = 0.80), or ED visits (males, 1.8 [11.3] and females, 1.5 [6.0], p = 0.24) per person. There were no sex differences in mean [SD] annual direct healthcare cost per patient (males, $80 334 [116 762] versus females, $81 010 [112 625], p = 0.90), but males received more specialist, multidisciplinary HF clinic, haemodialysis, and day surgical care, and females received more home visits, continuing/convalescent care, and long-term care. Annualized clinical events were highest in first year following index discharge in both males and females.

conclusionsAmong people discharged alive after hospitalization for HF, there were no sex differences in total and annual deaths, readmissions, and ED visits, or in total direct healthcare costs. Despite similar risk profiles, males received relatively more specialist care and day surgical procedures, and females received more supportive care. CLINICAL

trial registrationClinicalTrials.gov NCT02112227.

Indexed as

Health ResourcesHeart FailureHospitalizationPatient Acceptance of Health CareAgedCanadaEmergency Service, HospitalFemaleHumansMaleMiddle AgedPatient ReadmissionSex FactorsClinical outcomesHealth economicsHeart failureSex

Identifiers

PMID39498574
PMCPMC11860730

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.