Evidence map›Paper›PMID 39499248›Full record

ReviewPhysiology (Bethesda, Md.)2025

Olfactory Development and Dysfunction: Involvement of Microglia.

Sarah J Meller, Charles A Greer

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah J MellerDepartments of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, United States.
Charles A GreerDepartments of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, United States.ORCID 0000-0002-1289-1440

Funding

NEUROBIOLOGY OF CORTICAL SYSTEMST32NS007224 · NINDS · YALE UNIVERSITY · PI CARDIN, JESSICA A · 1985 to 2025
$4.6M
Piriform cortex: sequential developmental eventsR01DC013791 · NIDCD · YALE UNIVERSITY · PI Charles A Greer · 2015 to 2026
$3.9M
Dynamic interactions among olfactory sensory neuron axonsR01DC017989 · NIDCD · YALE UNIVERSITY · PI GREER, CHARLES A · 2019 to 2023
$2.1M
Olfactory Bulb Local CircuitsR01DC016851 · NIDCD · YALE UNIVERSITY · PI GREER, CHARLES A · 2019 to 2023
$1.8M
The Olfactory NerveR01DC012441 · NIDCD · YALE UNIVERSITY · PI GREER, CHARLES A · 2012 to 2016
$1.8M
HHS | National Institutes of Health (NIH) R01016851HHS | National Institutes of Health (NIH) R01017989HHS | National Institutes of Health (NIH) RO1013791NIDCD NIH HHS R01 DC012441NIDCD NIH HHS R01 DC013791NIDCD NIH HHS R01 DC016851NIDCD NIH HHS R01 DC017989NINDS NIH HHS T32 NS007224Whitehall Foundation (Whitehall Foundation, Inc.) No number
6 · The paper itself

Abstract

Olfactory deficits are increasingly recognized in a variety of neurological, neurodevelopmental, psychiatric, and viral diseases. While the pathology underlying olfactory loss is likely to differ across diseases, one shared feature may be an immune response mediated by microglia. Microglia orchestrate the brain's response to environmental insults and maintain neurodevelopmental homeostasis. Here, we explore the potential involvement of microglia in olfactory development and loss in disease. The effects of microglia-mediated immune response during development may be of special relevance to the olfactory system, which is unique in both its vulnerability to environmental insults as well as its extended period of neurogenesis and neuronal migration.

Indexed as

MicrogliaOlfaction DisordersAnimalsHumansNeurogenesisOlfactory BulbOlfactory PathwaysSmelldevelopmentdiseaseimmune systemmicrogliaolfaction

Identifiers

PMID39499248
PMCPMC12183649

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.