Evidence map›Paper›PMID 39499645›Full record

ArticleeLife2024

Molecular basis of neurodegeneration in a mouse model of

Robyn D Moir, Emilio Merheb, Violeta Chitu, E Richard Stanley, Ian M Willis

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Robyn D Moir *Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States.
Emilio Merheb *Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States.
Violeta ChituDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, United States.
E Richard StanleyDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, United States.ORCID https://orcid.org/0000-0002-2910-2065
Ian M WillisDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, United States.ORCID https://orcid.org/0000-0001-6599-2395

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Support for the Rose F. Kennedy IDDRCU54HD090260 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SCHWARTZ, GARY J · 2016 to 2020
$6.0M
Studies on RNA polymerase III-related leukodystrophyR01NS129951 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI IAN M WILLIS · 2023 to 2026
$2.7M
Advanced Confocal Microscope in a multi-user facilityS10OD023591 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BAKER, NICHOLAS E · 2017 to 2017
$590k
High Speed, High Resolution Slide Scanner for Research in Translational MedicineS10OD026852 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CONDEELIS, JOHN S · 2022 to 2022
$472k
A whole body model of Pol III-related leukodystrophyR21NS123730 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MOIR, ROBYN, WILLIS, IAN M · 2021 to 2021
$462k
NCI NIH HHS P30 CA013330NICHD NIH HHS P50 HD105352NICHD NIH HHS U54 HD090260NIH HHS R21 NS123730NIH HHS RO1 NS129951NIH HHS S10 OD023591NIH HHS S10 OD026852NINDS NIH HHS R01 NS129951NINDS NIH HHS R21 NS123730
6 · The paper itself

Abstract

Pathogenic variants in subunits of RNA polymerase (Pol) III cause a spectrum of

Indexed as

Disease Models, AnimalNeurodegenerative DiseasesRNA Polymerase IIIAnimalsGene Expression ProfilingMiceMutationRNA, TransferRNA Polymerase IIIRNA, Transferchromosomesgene expressioninnate immune responseintegrated stress responsemouseneurodegenerationneurosciencePolr3-related diseaseRNA polymerase IIItRNA

Identifiers

PMID39499645
PMCPMC11537486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.