Evidence map›Paper›PMID 39499658›Full record

ReviewEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2024

Ventricular arrhythmias in association with athletic cardiac remodelling.

Paolo D'Ambrosio, Guido Claessen, Peter M Kistler, Hein Heidbuchel, Jonathan M Kalman, André La Gerche

Abstract readReview
In one paragraph

Review in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Programmed ventricular stimulation for risk stratification in symptomatic athletes with nonischemic left ventricular scar and preserved ejection fraction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Characteristics of sudden cardiac arrest during endurance racing: a decade of the Paris registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  3. Lessons from the finish line: understanding cardiac arrest in endurance racing.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paolo D'AmbrosioDepartment of Medicine, The University of Melbourne, Grattan St, Parkville, VIC 3010, Australia.ORCID 0000-0002-8459-2140
Guido ClaessenFaculty of Medicine and Life Sciences, LCRC, UHasselt, Biomedical Research Institute, Diepenbeek, Belgium.ORCID 0000-0001-8261-6666
Peter M KistlerDepartment of Medicine, The University of Melbourne, Grattan St, Parkville, VIC 3010, Australia.ORCID 0000-0001-5369-5844
Hein HeidbuchelDepartment of Cardiology, Antwerp University Hospital, Antwerp, Belgium.ORCID 0000-0001-9301-8127
Jonathan M KalmanDepartment of Medicine, The University of Melbourne, Grattan St, Parkville, VIC 3010, Australia.ORCID 0000-0002-6618-7184
André La GercheDepartment of Medicine, The University of Melbourne, Grattan St, Parkville, VIC 3010, Australia.ORCID 0000-0002-3906-3784

Funding

Heart FoundationNational Health and Medical Research CouncilRoyal Australia College of Physicians Research Entry Scholarship
6 · The paper itself

Abstract

Athletes are predisposed to atrial arrhythmias but the association between intense endurance exercise training, ventricular arrhythmias (VAs), and sudden cardiac death is less well established. Thus, it is unclear whether the 'athlete's heart' promotes specific arrhythmias or whether it represents a more general pro-arrhythmogenic phenotype. Whilst direct causality has not been established, it appears possible that repeated exposure to high-intensity endurance exercise in some athletes contributes to formation of pro-arrhythmic cardiac phenotypes that underlie VAs. Theories regarding potential mechanisms for exercise-induced VAs include repeated bouts of myocardial inflammation and stretch-induced cellular remodelling. Small animal models provide some insights, but larger animal and human data are sparse. The current clinical approach to VAs in athletes is to differentiate those with and without structural or electrical heart disease. However, if the athlete's heart involves a degree of pro-arrhythmogenic remodelling, then this may not be such a simple dichotomy. Questions are posed by athletes with VAs in combination with extreme remodelling. Some markers, such as scar on magnetic resonance imaging, may point towards a less benign phenotype but are also quite common in ostensibly healthy athletes. Other clinical and invasive electrophysiology features may be helpful in identifying the at-risk athlete. This review seeks to discuss the association between athletic training and VAs. We will discuss the potential mechanisms, clinical significance, and approach to the management of athletes with VAs.

Indexed as

AthletesCardiomegaly, Exercise-InducedDeath, Sudden, CardiacVentricular RemodelingAnimalsArrhythmias, CardiacHumansRisk FactorsTachycardia, VentricularArrhythmogenic cardiomyopathyAthleteAthlete’s heartElectroanatomic mappingElectrophysiology studyEndurance athleteNon-ischaemic LV scarPremature ventricular complexSudden cardiac deathVentricular arrhythmiasVentricular tachycardia

Identifiers

PMID39499658
PMCPMC11641426

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.