Evidence map›Paper›PMID 39499804›Full record

ArticleEnvironmental science & technology2024

Comparative Proteomics Highlights that GenX Exposure Leads to Metabolic Defects and Inflammation in Astrocytes.

Abdulla Abu-Salah, Müberra Fatma Cesur, Aiesha Anchan, Muhammet Ay, Monica R Langley, Ahmed Shah, Pablo Reina-Gonzalez, Rachel Strazdins, Tunahan Çakır, Souvarish Sarkar

Abstract read
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In one paragraph

Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdulla Abu-SalahDepartment of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.
Müberra Fatma CesurDepartment of Bioengineering, Gebze Technical University, Gebze, KOCAELİ 41400, Turkey.ORCID 0000-0003-2993-0634
Aiesha AnchanDepartment of Neuroscience, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.
Muhammet AyDepartment of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.
Monica R LangleyDepartment of Molecular Pharmacology & Experimental Therapeutics, Department of Neurology, Department of Physical Medicine & Rehabilitation, Mayo Clinic, Gonda Building, 19th Floor, 200 First St. SW, Rochester, Minnesota 55905, United States.
Ahmed ShahDepartment of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.
Pablo Reina-GonzalezDepartment of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.
Rachel StrazdinsDepartment of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.ORCID 0009-0009-5565-6561
Tunahan ÇakırDepartment of Bioengineering, Gebze Technical University, Gebze, KOCAELİ 41400, Turkey.
Souvarish SarkarDepartment of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14620, United States.ORCID 0000-0002-7384-0508

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Katrina S Korfmacher · 1985 to 2026
$42.8M
Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
An in vivo multiplex model to study gene-environment interaction in Parkinson's DiseaseR00ES033723 · NIEHS · UNIVERSITY OF ROCHESTER · PI SARKAR, SOUVARISH · 2023 to 2025
$810k
An in vivo multiplex model to study gene-environment interaction in Parkinson's DiseaseK99ES033723 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI SARKAR, SOUVARISH · 2022 to 2022
$107k
NIEHS NIH HHS K99 ES033723NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R00 ES033723NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

Exposure to PFAS such as GenX (HFPO dimer acid) has become increasingly common due to the replacement of older generation PFAS in manufacturing processes. While neurodegenerative and developmental effects of legacy PFAS exposure have been studied in depth, there is a limited understanding specific to the effects of GenX exposure. To investigate the effects of GenX exposure, we exposed

Indexed as

AstrocytesDrosophila melanogasterInflammationProteomicsAnimalsParkinson DiseaseastrocytesbehaviorDrosophilaHFPO-DAnontargeted proteomics

Identifiers

PMID39499804
PMCPMC11580177

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.