Evidence map›Paper›PMID 39499953›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Coinfection of Leprosy and Chronic Mucocutaneous Candidiasis in a Family with STAT1 Gain-of-Function Mutation.

Lais Lima de Oliveira Rekowski, Gustavo Costa Caldas, Lucas Menezes-Silva, Camilla Natália Oliveira Santos, Lucas Sousa Magalhães, Rodrigo Anselmo Cazzaniga, Nailson Alves Dos Santos, Priscila Lima Santos, Ricardo Luís Louzada da Silva, Angela Maria da Silva and 2 more

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In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lais Lima de Oliveira RekowskiLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Gustavo Costa CaldasLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Lucas Menezes-SilvaDepartment of Medicine, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Camilla Natália Oliveira SantosLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Lucas Sousa MagalhãesLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Rodrigo Anselmo CazzanigaLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Nailson Alves Dos SantosDepartment of Medicine, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Priscila Lima SantosLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Ricardo Luís Louzada da SilvaLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Angela Maria da SilvaLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.
Steven M HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Amelia Ribeiro de JesusLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report documents the first known cases of lepromatous leprosy in patients with chronic mucocutaneous candidiasis (CMC) linked to a gain-of-function mutation in the STAT1 gene. Two related patients, a mother and daughter, who both suffer from CMC and lepromatous leprosy, carry a heterozygous STAT1 mutation (c.821G>A; p.R274Q). Both individuals exhibited similarly high levels of total and phosphorylated STAT1 in CD4+ T cells and decreased interleukin 17A transcripts. This mutation underscores a complex relationship between genetic susceptibility to infections and the necessity to evaluate each case individually.

Indexed as

Candidiasis, Chronic MucocutaneousGain of Function MutationSTAT1 Transcription FactorCD4-Positive T-LymphocytesCoinfectionFemaleGenetic Predisposition to DiseaseHumansInterleukin-17LeprosyInterleukin-17STAT1 protein, humanSTAT1 Transcription Factor

Identifiers

PMID39499953
PMCPMC11720780

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.