SynthesisNature medicine2025
A systematic review and meta-analysis of heat exposure impacts on maternal, fetal and neonatal health.
Synthesis in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07489664 (Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat), which is not on this map. Cited by 80 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat
Who cites it
80 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- A systematic review and meta-analysis on heat thresholds for maternal health and birth outcomes.Nature communications · 2026Pooled it
- Building the model: a review of input structures in extreme temperature-health.Environmental health : a global access science source · 2026Pooled it
- From conception to care: a systematic review of the impact of the climate crisis on reproductive justice.Sexual and reproductive health matters · 2025Pooled it
- The effects of prenatal psychosocial work stress on adverse pregnancy outcomes: A comprehensive systematic review and meta-analysis.Scandinavian journal of work, environment & health · 2025Pooled it
- Heat stress and maternal complications in India: A nationwide analysis using the universal thermal climate index.iScience · 2026Article
- Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Seizures in children with Dravet syndrome in extreme heat: A qualitative study of parental perspectives.Developmental medicine and child neurology · 2026Article
- Crisis epilépticas en niños con síndrome de Dravet en condiciones de calor extremo: estudio cualitativo de la perspectiva de los progenitores.Developmental medicine and child neurology · 2026Article
- The Impact of Climate Change on Pregnant Women's Health: A Scoping Review of Reviews.Nursing reports (Pavia, Italy) · 2026Review
- Association between extreme heat exposure and risk of preterm birth and its effect modifiers: a systematic review and meta-analysis.Journal of exposure science & environmental epidemiology · 2026Article
- Nurturing People and Planet: Breastfeeding in Climate Mitigation and Adaptation.Frontiers in sustainable food systems · 2026Article
- Prenatal and Early Childhood Ambient Heat Exposure and Developmental Outcomes: A Systematic Review.Clinical child and family psychology review · 2026Review
- Chlorogenic Acid Alleviates Heat Stress-Induced Fetal Growth Restriction Through Gut-Placental Crosstalk by Reshaping Gut Microbiota and Mediating Keap1-Nrf2 Antioxidant Signaling.Antioxidants (Basel, Switzerland) · 2026Article
- Ambient temperature and exclusive breastfeeding: a nationwide cohort study in Brazil.International journal of epidemiology · 2026Article
- Review
- Association between first trimester ambient temperature and the risk of gestational hypertension and pre-eclampsia: Insights from the PRECISE study cohort in The Gambia, Kenya and Mozambique.Research square · 2026Article
- Universal Thermal Climate Index and Gestational Diabetes Mellitus Risk: Effect Modification by Green Space in a Chinese Prospective Cohort.BMC public health · 2026Article
- Article
- Gene-Temperature Interactions and Risk of Childhood Acute Lymphoblastic Leukemia.medRxiv : the preprint server for health sciences · 2026Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
13 authors.
Funding
Abstract
Climate change has severe and wide-ranging health impacts, especially for vulnerable groups. Despite growing evidence of heat-associated adverse maternal and neonatal health outcomes, there remains a lack of synthesis quantifying associations and identifying specific risk periods. We systematically reviewed the literature on heat impacts on maternal, fetal and neonatal health and quantified impacts through meta-analyses. We found 198 studies across 66 countries, predominantly high income (63.3%) and temperate climate zones (40.1%), and 23 outcomes. Results showed increased odds of preterm birth of 1.04 (95% confidence interval (CI) = 1.03, 1.06; n = 12) per 1 °C increase in heat exposure and 1.26 (95% CI = 1.08, 1.47; n = 10) during heat waves. Similarly, high heat exposure increased the risk for stillbirths (odds ratio (OR) = 1.13 (95% CI = 0.95, 1.34; n = 9)), congenital anomalies (OR = 1.48 (95% CI = 1.16, 1.88; n = 6)) and gestational diabetes mellitus (OR = 1.28 (95% CI = 1.05, 1.74; n = 4)). The odds of any obstetric complication increased by 1.25 (95% CI = 1.09, 1.42; n = 11) during heat waves. Patterns in susceptibility windows varied by condition. The findings were limited by heterogeneity in exposure metrics and study designs. The systematic review demonstrated that escalating heat exposure poses a major threat to maternal and neonatal health, highlighting research priorities, guiding the selection and monitoring of heat-health indicators and emphasizing the need to prioritize maternal and neonatal health in national climate health programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.