Implication of vasopressin receptor genes (AVPR1A and AVPR1B) in the susceptibility to polycystic ovary syndrome.

Pruthvi Goparaju, Claudia Gragnoli

Abstract read

In one paragraph

Article in Journal of ovarian research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mapping burdens and inequalities of polycystic ovary syndrome in young females across 953 locations 1990-2040 with deep learning forecasts.iScience · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pruthvi GoparajuDivision of Endocrinology, Department of Medicine, Creighton University School of Medicine, Omaha, NE, 68124, USA.

Claudia GragnoliDivision of Endocrinology, Department of Medicine, Creighton University School of Medicine, Omaha, NE, 68124, USA. claudia.gragnoli@gmail.com.

Funding

Nebraska Department of Health and Human Services This publication was supported in part with the funds received under Nebraska Laws 2021, LB 380, Section 109.

6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is a complex heterogenous disorder manifesting with various reproductive, endocrine, and metabolic derangements such as insulin resistance and hyperglycemia. The arginine vasopressin peptide (AVP), also called or antidiuretic hormone (ADH), modulates metabolic functions such as glucose hemostasis, insulin sensitivity, and lipid metabolism via binding to two central and peripheral receptors (AVPR1A and AVPR1B). In the present study, we aimed to detect whether the AVPR1A and AVPR1B genes confer risk for PCOS.

methodsIn peninsular Italian families, we tested 7 variants in the AVPR1B gene and 2 variants in the AVPR1A gene via Pseudomarker for linkage and linkage joint to association (i.e.., linkage disequilibrium) with PCOS.

resultsWe identified two risk variants in each gene, significantly associated with the risk of PCOS.

conclusionTo the best of our knowledge, this is the first study to report risk variants in AVPR1A and AVPR1B genes in association with PCOS. However, replication in other ethnic groups as well as functional studies are needed to confirm these results.

Indexed as

Genetic Predisposition to DiseasePolycystic Ovary SyndromeReceptors, VasopressinAdultFemaleGenotypeHumansItalyLinkage DisequilibriumPolymorphism, Single NucleotideAVPR1A protein, humanAVPR1b protein, humanReceptors, VasopressinArginine vasopressin receptor 1aArginine vasopressin receptor 1bCortisolHypothalamic–pituitary–adrenal axisInsulin resistanceLinkage disequilibriumParametric analysisPolycystic ovary syndromeSingle nucleotide polymorphismsType 2 diabetes

Identifiers

PMID39501331

DOI10.1186/s13048-024-01515-z

PMCPMC11536872

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.