Evidence map›Paper›PMID 39502000›Full record

ArticleEuropean journal of immunology2025

The VEGF-Mediated Cytoprotective Ability of MIF-Licensed Mesenchymal Stromal Cells in House Dust Mite-Induced Epithelial Damage.

Hazel Dunbar, Ian J Hawthorne, Courteney Tunstead, Molly Dunlop, Evelina Volkova, Daniel J Weiss, Claudia C Dos Santos, Michelle E Armstrong, Seamas C Donnelly, Karen English

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The PPARβ/Delta-Induced Mesenchymal Stromal Cell Secretome Has Cytoprotective Effects via ANGPTL4 in a Pre-Clinical Model of Acute Lung Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hazel DunbarKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
Ian J HawthorneKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
Courteney TunsteadKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
Molly DunlopKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
Evelina VolkovaKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
Daniel J WeissDepartment of Medicine, 226 Health Sciences Research Facility, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Claudia C Dos SantosThe Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, Ontario, Canada.
Michelle E ArmstrongDepartment of Medicine, Trinity College Dublin and Tallaght Hospital, Dublin, Ireland.
Seamas C DonnellyDepartment of Medicine, Trinity College Dublin and Tallaght Hospital, Dublin, Ireland.
Karen EnglishKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.

Funding

HEA COVID grant to Maynooth UniversityHigher Education AuthorityIrish Research Council IRCLA/2017/288Science Foundation Ireland 12/RI/2346
6 · The paper itself

Abstract

Enhancing mesenchymal stromal cell (MSC) therapeutic efficacy through licensing with proinflammatory cytokines is now well established. We have previously shown that macrophage migration inhibitory factor (MIF)-licensed MSCs exerted significantly enhanced therapeutic efficacy in reducing inflammation in house dust mite (HDM)-driven allergic asthma. Soluble mediators released into the MSC secretome boast cytoprotective properties equal to those associated with the cell itself. In asthma, epithelial barrier damage caused by the inhalation of allergens like HDM drives goblet cell hyperplasia. Vascular endothelial growth factor (VEGF) plays a pivotal role in the repair and maintenance of airway epithelial integrity. Human bone marrow-derived MSCs expressed the MIF receptors CD74, CXCR2, and CXCR4. Endogenous MIF from high MIF expressing CATT

Indexed as

AsthmaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMesenchymal Stem CellsPyroglyphidaeVascular Endothelial Growth Factor AAnimalsAntigens, Differentiation, B-LymphocyteCell MovementCells, CulturedGoblet CellsHistocompatibility Antigens Class IIHumansMacrophagesMiceReceptors, CXCR4Antigens, Differentiation, B-LymphocyteCXCR4 protein, humanHistocompatibility Antigens Class IIIntramolecular Oxidoreductasesinvariant chainMacrophage Migration-Inhibitory FactorsMIF protein, humanReceptors, CXCR4Receptors, Interleukin-8BVascular Endothelial Growth Factor Aairway epithelialhouse dust mitemacrophage migration inhibitory factormesenchymal stromal cellsvascular endothelial growth factor

Identifiers

PMID39502000
PMCPMC11739667

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.