Evidence map›Paper›PMID 39502034›Full record

ReviewStroke2025

Interfacility Transfer for Thrombectomy: A Promising Therapeutic Window.

Pierre Seners, Jean-Claude Baron, Anke Wouters, Jean-Philippe Desilles, Fernando Pico, Richard Macrez, Jean-Marc Olivot, Robin Lemmens, Gregory W Albers, Maarten G Lansberg

Abstract readReview
In one paragraph

Review in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Thrombectomy-capable vs. comprehensive stroke centers: impact on endovascular therapy outcomes in acute large vessel occlusion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pierre SenersNeurology Department, Rothschild Foundation Hospital, Paris, France (P.S.).ORCID 0000-0002-2134-0691
Jean-Claude BaronInstitut de Psychiatrie et Neurosciences de Paris, U1266, INSERM, France (P.S., J.-C.B.).ORCID 0000-0002-5264-2588
Anke WoutersKU Leuven, Department of Neurosciences, Experimental Neurology; University Hospitals Leuven, Department of Neurology, Belgium (A.W., R.L.).ORCID 0000-0001-5229-2699
Jean-Philippe DesillesStrokeLink, French Clinical Research Infrastructure Network (F-CRIN), France (P.S., J.-P.D., F.P., R.M., J.-M.O.).ORCID 0000-0001-8395-6312
Fernando PicoStrokeLink, French Clinical Research Infrastructure Network (F-CRIN), France (P.S., J.-P.D., F.P., R.M., J.-M.O.).ORCID 0000-0002-3329-5365
Richard MacrezStrokeLink, French Clinical Research Infrastructure Network (F-CRIN), France (P.S., J.-P.D., F.P., R.M., J.-M.O.).ORCID 0000-0003-1388-9630
Jean-Marc OlivotStrokeLink, French Clinical Research Infrastructure Network (F-CRIN), France (P.S., J.-P.D., F.P., R.M., J.-M.O.).ORCID 0000-0003-2027-2276
Robin LemmensKU Leuven, Department of Neurosciences, Experimental Neurology; University Hospitals Leuven, Department of Neurology, Belgium (A.W., R.L.).ORCID 0000-0002-4948-5956
Gregory W AlbersStanford Stroke Center, Stanford University, Palo Alto, CA (G.W.A., M.G.L.).ORCID 0000-0003-0263-4632
Maarten G LansbergStanford Stroke Center, Stanford University, Palo Alto, CA (G.W.A., M.G.L.).ORCID 0000-0002-3545-6927

Funding

CTP to predict Response to recanalization in Ischemic Stroke Project (CRISP)R01NS075209 · NINDS · STANFORD UNIVERSITY · PI LANSBERG, MAARTEN G · 2011 to 2023
$6.0M
NINDS NIH HHS R01 NS075209
6 · The paper itself

Abstract

Currently, most acute ischemic stroke patients presenting with a large vessel occlusion are first evaluated at a nonthrombectomy-capable center before transfer to a comprehensive stroke center that performs thrombectomy. Interfacility transfer is a complex process that requires extensive coordination between the referring, transporting, and receiving facilities. As a result, long delays are common, contributing to poor clinical outcomes. In this review, we summarize the accumulating literature about the clinical as well as radiological-infarct growth, collateral change, arterial recanalization, and hemorrhagic transformation-changes during interfacility transfer for thrombectomy. Recent evidence shows that clinical/radiological changes during transfer are heterogeneous across patients and impact long-term functional outcomes, highlighting the urgent need to optimize care during this time window. We review some of the most promising therapeutic strategies-for example, penumbral protection to reduce infarct growth-that may improve clinical outcome in patients being transferred to thrombectomy-capable centers. Finally, we discuss key methodological considerations for designing clinical trials aimed at reducing infarct growth during transfer.

Indexed as

Ischemic StrokePatient TransferStrokeThrombectomyHumansTime-to-Treatmentarteriesinfarctionischemic strokestrokethrombectomy

Identifiers

PMID39502034
PMCPMC11772119

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.