Evidence map›Paper›PMID 39502179›Full record

ArticleRSC advances2024

Assessment of optimized FRET substrates as universal corona- and picornavirus main protease substrates for screening assays.

Conrad Fischer, Tayla J Van Oers, Marco J van Belkum, Tess Lamer, Aaron Romney, Pu Chen, M Joanne Lemieux, John C Vederas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Conrad FischerDepartment of Chemistry, University of Alberta Edmonton AB T6G 2G2 Canada john.vederas@ualberta.ca.ORCID https://orcid.org/0000-0002-2289-010X
Tayla J Van OersDepartment of Chemistry, University of Alberta Edmonton AB T6G 2G2 Canada john.vederas@ualberta.ca.ORCID https://orcid.org/0009-0006-2314-560X
Marco J van BelkumDepartment of Chemistry, University of Alberta Edmonton AB T6G 2G2 Canada john.vederas@ualberta.ca.ORCID https://orcid.org/0000-0002-9296-6069
Tess LamerDepartment of Chemistry, University of Alberta Edmonton AB T6G 2G2 Canada john.vederas@ualberta.ca.ORCID https://orcid.org/0000-0002-1511-4540
Aaron RomneyDepartment of Chemistry, University of Alberta Edmonton AB T6G 2G2 Canada john.vederas@ualberta.ca.
Pu ChenDepartment of Biochemistry, Membrane Protein Disease Research Group, University of Alberta Edmonton AB T6G 2R3 Canada.
M Joanne LemieuxDepartment of Biochemistry, Membrane Protein Disease Research Group, University of Alberta Edmonton AB T6G 2R3 Canada.ORCID https://orcid.org/0000-0003-4745-9153
John C VederasDepartment of Chemistry, University of Alberta Edmonton AB T6G 2G2 Canada john.vederas@ualberta.ca.ORCID https://orcid.org/0000-0002-2996-0326

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronaviral infections are an important cause of enteric and respiratory diseases in humans and animals that are generally associated with a high level of morbidity and mortality. Similarly, picornavirus infections can lead to various illnesses that severely impact human and animal health. Despite belonging to different virus families, viral replication in all of these pathogens relies on the action of a central cysteine protease called 3C/3CL or main protease (M

Identifiers

PMID39502179
PMCPMC11537199

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.