ArticleJournal of animal science2024
Exploring optimal folic acid supplementation levels for lactating-pregnant rabbit does with different litter size.
Article in Journal of animal science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Folate as a Key Regulator of Animal Intestinal Homeostasis: From Metabolism to Microbiota and Barrier Function.Animals : an open access journal from MDPI · 2026Review
- Temporal Dynamics of Fecal Microbiome and Short-Chain Fatty Acids in Sows from Early Pregnancy to Weaning.Animals : an open access journal from MDPI · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
The lactation-pregnancy overlap in the industrialized 49-d breeding model increases nutritional demands for lactating-pregnant rabbit does. This study examined the effects of folic acid (FA) on the production performance and intestinal microflora of does with different litter sizes (LS, or number of kits). A total of 144 third-parity Hyplus does, aged 11 mo and weighing approximately 5.00 ± 0.07 kg, were divided into 4 treatment groups: control group (basal diet) and FA groups (basal diet + 15, 30, and 45 mg/kg FA). Does with LS of 5, 7, and 9 were selected after weaning. Our findings revealed that 1) Increased FA supplementation initially increased and then decreased the pre-lactation body weight of 21-d-old kits and prolactin (PRL) level of lactating does, while showing an inverse trend for estrogen (E) level of does. Increased LS significantly (P < 0.05) correlated with reduced milk yield of does. There was a significant (P < 0.05) interaction between FA and LS affecting PRL, E, growth hormone levels of does, and the pre-lactation body weight of 21-d-old kits; 2) Increased FA supplementation initially increased and then decreased the post-lactation body weight of 21-d-old and 35-d-old kits, elevated plasma FA (PFA) level of lactating-pregnant does, and significantly (P < 0.05) impacted the pregnancy rate of does. Increased LS was associated with reduced post-lactation body weight in 21-d-old and 35-d-old kits (P < 0.05). There was a significant (P < 0.05) interaction between FA and LS affecting plasma insulin-like growth factor-1 (IGF-1), homocysteine (HCY), PFA levels of does, the post-lactation body weight of 21-d-old kits, and weaning body weight of 35-d-old kits; and 3) FA supplementation promoted the growth of Ruminococcaceae and Rikenellaceae_RC9_gut_group in the feces of lactating-pregnant does, as well as the proliferation of Lachnospiraceae_NK4A136_group in the feces of pregnant does, suggesting enhanced anti-inflammatory properties and improved crude fiber breakdown. In summary, FA supplementation improved conception rates, regulated lactation-related hormone synthesis and secretion, increased body weight of 21-d-old kits, and enhanced intestinal anti-inflammatory functions.
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