Evidence map›Paper›PMID 39503754›Full record

ArticleActa neuropathologica2024

TMEM106B amyloid filaments in the Biondi bodies of ependymal cells.

Bernardino Ghetti, Manuel Schweighauser, Max H Jacobsen, Derrick Gray, Mehtap Bacioglu, Alexey G Murzin, Bradley S Glazier, Taxiarchis Katsinelos, Ruben Vidal, Kathy L Newell and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA. bghetti@iu.edu.ORCID 0000-0002-1842-8019
Manuel SchweighauserMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Max H JacobsenDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Derrick GrayCenter for Electron Microscopy, Indiana University School of Medicine, Indianapolis, USA.
Mehtap BaciogluDepartment of Clinical Neurosciences, Cambridge University, Cambridge, UK.
Alexey G MurzinMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Bradley S GlazierDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Taxiarchis KatsinelosMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Ruben VidalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Kathy L NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Sujuan GaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, USA.
Holly J GarringerDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Maria Grazia SpillantiniDepartment of Clinical Neurosciences, Cambridge University, Cambridge, UK.
Sjors H W ScheresMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Michel GoedertMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's diseaseR01AG075802 · NIA · MAYO CLINIC JACKSONVILLE · PI BERNARDINO Francesco GHETTI, Lea Tenenholz Grinberg · 2022 to 2026
$15.5M
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Atomic models of human tau filaments and development of tau ligandsU01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2018 to 2022
$3.5M
Investigating the role of TDP-43 mislocalization, structure, and post-translational modifications in the neuropathologically heterogeneous TDP-43 proteinopathiesR01NS137469 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI Laura Cracco, Kathy L Newell · 2024 to 2026
$3.0M
Structure of amyloid fibrils in human neurodegenerative diseases and agingR01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BERNARDINO Francesco GHETTI, Wen Jiang · 2026 to 2026
$1.2M
Medical Research Council MC_U105184291Medical Research Council MC_UP_A025-1013NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG060477NIA NIH HHS R01 AG075802NIHR Cambridge Biomedical Research Centre NIHR 203312NINDS NIH HHS R01 NS110437NINDS NIH HHS R01 NS137469NINDS NIH HHS U01 NS110437
6 · The paper itself

Abstract

Biondi bodies are filamentous amyloid inclusions of unknown composition in ependymal cells of the choroid plexuses, ependymal cells lining cerebral ventricles and ependymal cells of the central canal of the spinal cord. Their formation is age-dependent and they are commonly associated with a variety of neurodegenerative conditions, including Alzheimer's disease and Lewy body disorders. Here, we show that Biondi bodies are strongly immunoreactive with TMEM239, an antibody specific for inclusions of transmembrane protein 106B (TMEM106B). Biondi bodies were labelled by both this antibody and the amyloid dye pFTAA. Many Biondi bodies were also labelled for TMEM106B and the lysosomal markers Hexosaminidase A and Cathepsin D. By transmission immuno-electron microscopy, Biondi bodies of choroid plexuses were decorated by TMEM239 and were associated with structures that resembled residual bodies or secondary lysosomes. By electron cryo-microscopy, TMEM106B filaments from Biondi bodies of choroid plexuses were similar (Biondi variant), but not identical, to the fold I that was previously identified in filaments from brain parenchyma.

Indexed as

Choroid PlexusEpendymaInclusion BodiesMembrane ProteinsNerve Tissue ProteinsAgedAmyloidAnimalsFemaleHumansLysosomesMaleAmyloidMembrane ProteinsNerve Tissue ProteinsTMEM106B protein, humanAmyloidBiondi bodiesElectron cryo-microscopyEpendymal cellsLysosomesTransmembrane protein 106B

Identifiers

PMID39503754
PMCPMC11541264

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.