Evidence map›Paper›PMID 39503777›Full record

ArticleEuropean child & adolescent psychiatry2025

Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.

Olga Bienek, Kelly Allott, Linda Antonucci, Alessandro Bertolino, Carolina Bonivento, Stephan Borgwardt, Paolo Brambilla, Katharine Chisholm, Udo Dannlowski, Theresa K Lichtenstein and 19 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Olga BienekClinic for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Muenster, Schmeddingstrasse 50, 48149, Muenster, Germany. Olga.bienek@web.de.
Kelly AllottCentre for Youth Mental Health, University of Melbourne, Parkville, Australia.
Linda AntonucciDepartment of Education, Psychology, and Communication, University of Bari Aldo Moro, Bari, Italy.
Alessandro BertolinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Carolina BoniventoPasian Di Prato (UD), Scientific Institute IRCCS 'Eugenio Medea', Polo FVG, 33037, Udine, Italy.
Stephan BorgwardtClinic for Psychiatry and Psychotherapy, University Hospital Luebeck, Lübeck, Germany.
Paolo BrambillaDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Katharine ChisholmSchool of Psychology, Sussex University, Brighton, UK.
Udo DannlowskiInstitute for Translational Psychiatry, University Hospital Muenster, Münster, Germany.
Theresa K LichtensteinDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Joseph KambeitzDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Lana Kambeitz-IlankovicDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
Rebekka LencerInstitute for Translational Psychiatry, University Hospital Muenster, Münster, Germany.
Siân Lowri GriffithsInstitute for Mental Health, University of Birmingham, Birmingham, UK.
Eleonora MaggioniDepartment of Electronics, Information and Bioengineering, Politecnico Di Milano, Milan, Italy.
Eva MeisenzahlDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Christos PantelisMelbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Australia.
Marlene RosenDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Stephan RuhrmannDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Raimo K R SalokangasDepartment of Psychiatry, University of Turku, Turku, Finland.
Alexandra StaintonCentre for Youth Mental Health, University of Melbourne, Parkville, Australia.
Marian SurmannInstitute for Translational Psychiatry, University Hospital Muenster, Münster, Germany.
Rachel UpthegroveInstitute for Mental Health, University of Birmingham, Birmingham, UK.
Julian WenzelDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Stephen J WoodCentre for Youth Mental Health, University of Melbourne, Parkville, Australia.
Georg Romer *Clinic for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Muenster, Schmeddingstrasse 50, 48149, Muenster, Germany.
Jörg Michael Müller *Clinic for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Muenster, Schmeddingstrasse 50, 48149, Muenster, Germany.
PRONIA Consortium

Funding

Training the next generation of clinical neuroscientistsT32MH122394 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rene S. Kahn, ANTONIA S NEW · 2020 to 2026
$2.5M
EU under the 7th Framework Programme 602152NIMH NIH HHS T32 MH122394
6 · The paper itself

Abstract

The aim of this study was to examine the neurocognitive deficits associated with the first episode of major depressive disorder (recent onset depression, ROD) in adolescents as compared to adult patients. Cross-sectional neurocognitive data from the baseline assessments of the PRONIA study with N = 650 (55.31% females) were analyzed. Based on a principal component analysis of eleven neurocognitive tests, we constructed an overall neurocognitive performance (NP) score. We examined mean score differences in NP between the groups of healthy controls (HC) and ROD and between adolescents (15-21 years) and adults (22-40 years) within a GLM approach. This accounts for unbalanced data with focus on interaction effects while controlling for effects of medication and educational years. Our results show lower NP for the ROD as compared to the HC group (d = - 0.29, p = .046) and lower NP for the adolescent group as compared to the adult group (d = - 0.29; p < .039). There was no interaction between these two group effects (F = 1.11; p = .29). Our findings suggest that the detrimental effect of ROD on neurocognitive functioning is comparable in adolescent and adult patients, since lower scores in adolescent patients are explained by effects of age and education. Neurocognitive impairment is an under addressed issue in clinical treatment guidelines for adolescent MDD. We suggest efficient monitoring in clinical practice by using an aggregate of the Digit Symbol Substitution Test and the Trail Making Test B, which highly correlated with the overall score of NP (r = 0.82).

Indexed as

Cognitive DysfunctionMajor Depressive DisorderAdolescentAdultCross-Sectional StudiesFemaleHumansMaleNeuropsychological TestsYoung AdultAdolescentMajor depressive disorderNeurocognitive dysfunctionPRONIARecent onset

Identifiers

PMID39503777
PMCPMC12198262

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.