ArticleNPJ biofilms and microbiomes2024
Large-scale metagenomic assembly provide new insights into the genetic evolution of gut microbiomes in plateau ungulates.
Article in NPJ biofilms and microbiomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- IgA Deficiency Exacerbates an Animal Model of Multiple Sclerosis Induced with Theiler's Virus.Cells · 2026Article
- Untapped enzymatic potential: dehalogenase- and peroxidase-driven PVC degradation by gene carriers in Tibetan plateau pikas.Microbiome · 2026Article
- Comparative analysis of gut virome signatures between ducks raised in aquatic and dryland environments.Poultry science · 2026Article
- Gut microbial genetic variations are associated with exploratory behavior via SNV-driven metabolic regulation in a sheep model.Science China. Life sciences · 2026Article
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- RuSpacer: a CRISPR spacer database derived from ruminant-associated prokaryotes for virome analysis.Scientific reports · 2026Article
- DNA methylation-mediated regulation of hypoxia-responsive genes facilitates high-altitude adaptation in Tibetan chickens.Poultry science · 2026Article
- Gut Microbiome Signatures of Aging Associated with Intramuscular Fat Deposition in Tan Sheep.Animals : an open access journal from MDPI · 2026Article
- Post-defecation exposure alters gut microbiota of forest musk deer with implications for conservation metagenomics.Applied microbiology and biotechnology · 2026Article
- Blastocystis infection enhances vitamins B and KBMC genomics · 2026Article
- Article
- From forest to farm: the impact of a broad spectrum of lifestyles on the porcine gut microbiota.Current research in microbial sciences · 2026Article
- Seasonal dietary shifts drive gut microbiome plasticity and metabolic adaptation in wild yaks on the Qinghai-Xizang Plateau.BMC microbiology · 2025Article
- Gut Microbiome of Two Rodent Species (Animals : an open access journal from MDPI · 2025Article
- Metagenome-Based Functional Differentiation of Gut Microbiota and Ecological Adaptation Among Geographically Distinct Populations of Przewalski's Gazelle (Microorganisms · 2025Article
- Effects of Supplementation with Chlorogenic Acid-Rich Extract fromVeterinary sciences · 2025Article
- The plasticity of gut microbiota contributes to inter-region dietary differences adaptation of ungulates in the Qinghai-Tibet Plateau.mSystems · 2025Article
- The crosstalk between host and rumen microbiome in cattle: insights from multi-omics approaches and genome-wide association studies.World journal of microbiology & biotechnology · 2025Review
- Review
- Gut microbiome and diet contribute to ecological niche differentiation between argali (Ovis ammon hodgsoni) and blue sheep (Pseudois nayaur) on the Qinghai-Tibet Plateau.Communications biology · 2025Article
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14 authors.
Funding
Abstract
Trillions of microbes colonize the ungulate gastrointestinal tract, playing a pivotal role in enhancing host nutrient utilization by breaking down cellulose and hemicellulose present in plants. Here, through large-scale metagenomic assembly, we established a catalog of 131,416 metagenome-assembled genomes (MAGs) and 11,175 high-quality species-level genome bins (SGBs) from 17 species of ungulates in China. Our study revealed the convergent evolution of high relative abundances of carbohydrate-active enzymes (CAZymes) in the gut microbiomes of plateau-dwelling ungulates. Notably, two significant factors contribute to this phenotype: structural variations in their gut microbiome genomes, which contain more CAZymes, and the presence of novel gut microbiota species, particularly those in the genus Cryptobacteroides, which are undergoing independent rapid evolution and speciation and have higher gene densities of CAZymes. Furthermore, these enrichment CAZymes in the gut microbiomes are highly enrichment in known metabolic pathways for short-chain fatty acid (SCFA) production. Our findings not only provide a valuable genomic resource for understanding the gut microbiomes of ungulates but also offer fresh insights into the interaction between gut microbiomes and their hosts, as well as the co-adaptation of hosts and their gut microbiomes to their environments.
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