Evidence map›Paper›PMID 39506687›Full record

ArticleBMC pediatrics2024

Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study.

Banga Mseza, Patrick Kumbakulu Kumbowi, Martin Nduwimana, Desire Banga, Emmanuel Tibasima Busha, Walufu Ivan Egesa, Richard Justin Odong, Grace Ndeezi

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Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Banga MsezaDepartment of Pediatrics and Child Health, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda. bangamseza@gmail.com.ORCID http://orcid.org/0000-0002-7817-5252
Patrick Kumbakulu KumbowiDepartment of Pediatrics and Child Health, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda.
Martin NduwimanaDepartment of Pediatrics and Child Health, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda.
Desire BangaDepartment of Pediatrics and Child Health, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda.
Emmanuel Tibasima BushaDepartment of Pediatrics and Child Health, Université Libre Des Pays Des Grands Lacs, Goma, Democratic Republic of Congo.
Walufu Ivan EgesaDepartment of Pediatrics, Nile International Hospital, Jinja, Uganda.
Richard Justin OdongDepartment of Pediatrics and Child Health, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda.
Grace NdeeziDepartment of Pediatrics and Child Health, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCerebral malaria, caused by Plasmodium falciparum, represents the most severe neurologic complication of malaria. Its association with high morbidity and mortality rates, especially among young children, underscores its clinical significance. In sub-Saharan Africa, including Uganda, cerebral malaria remains a major health challenge, contributing significantly to the high child mortality rate. Despite advances in malaria control, the burden of cerebral malaria among children under five is substantial, reflecting the need for targeted interventions and improved management strategies. This study aimed to determine the prevalence of cerebral malaria and identify associated factors among children admitted with severe malaria at a tertiary hospital in western Uganda.

methodsThis was a cross-sectional, descriptive, and analytical study involving children aged 6 to 59 months admitted with severe malaria. The study was conducted from January to March 2023 at Fort Portal Regional Referral Hospital. Severe and cerebral malaria were defined as per the WHO criteria. Sociodemographic, clinical, and laboratory data were collected and analyzed using IBM SPSS version 27. Logistic regression analysis was used to evaluate the factors associated with cerebral malaria. A p-value < 0.05 indicated statistical significance.

resultsA total of 250 children were recruited (mean age 33.1 ± 17.3 months). The prevalence of cerebral malaria was 12.8% (95% CI: 8.9-17.6). Cerebral malaria was independently associated with male sex (aOR: 3.05, 95% CI: 1.20-7.77, p = 0.02), abnormal bleeding (aOR: 13.22, 95% CI: 11.54-15.16, p = 0.001), history of convulsions (aOR 12.20, 95% CI: 10.7-21.69, p = 0.010), acute kidney injury (aOR: 4.50, 95% CI: 1.30-15.53, p = 0.02), and hyponatremia (aOR: 3.47, 95% CI: 1.34-8.96, p = 0.010). CONCLUSIONS AND RECOMMENDATIONS: The prevalence of cerebral malaria was high among children with severe malaria. Factors associated with cerebral malaria included male gender, history of convulsions, abnormal bleeding, acute kidney injury, and hyponatremia. Targeted interventions and early management are essential to improve clinical outcomes.

Indexed as

Malaria, CerebralChild, PreschoolCross-Sectional StudiesFemaleHumansInfantMalaria, FalciparumMalePrevalenceRisk FactorsSeverity of Illness IndexUgandaAssociated factorsCerebral malariaUgandaUnder-five

Identifiers

PMID39506687
PMCPMC11539429

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