Evidence map›Paper›PMID 39506756›Full record

Trial reportBMC oral health2024

Therapeutic effects of acyclovir and acyclovir-clobetasol nanofibers vs. cream formulation for recurrent herpes labialis.

Shahla Mirzaei, Zahra Golestan Nejad, Faezeh Khozaimeh, Solmaz Mohammadi, Alireza Loqmani

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shahla MirzaeiPharmaceutical Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Zahra Golestan NejadDental Research Center, Department of Diagnosis of Oral and Dental Diseases, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Faezeh KhozaimehDental Research Center, Department of Diagnosis of Oral and Dental Diseases, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Solmaz MohammadiStudent Research Committee, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. solmazmohamadi.dnt2@gmail.com.
Alireza LoqmaniStudent Research Committee, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to compare the therapeutic effects of acyclovir nanofiber and acyclovir-clobetasol nanofiber formulations with their non-nano formulations (cream formulation) on recurrent labial herpes. MATERIALS AND

methodsEighty patients with labial herpes lesions were divided into four groups, each receiving one of the following treatments: acyclovir-clobetasol nano patch, acyclovir-clobetasol cream, acyclovir nano patch, or acyclovir cream. Pain levels and recovery times were assessed. The Wilcoxon test compared pain levels, while the log-rank test compared healing and scabbing times.

resultsAcyclovir-clobetasol nanofiber and cream, along with acyclovir nanofiber, significantly reduced symptoms compared to the acyclovir cream. The recovery and scabbing times were shorter in patients who received acyclovir-clobetasol formulations compared to those receiving acyclovir alone.

conclusionAcyclovir-clobetasol combinations accelerated recovery times compared to acyclovir alone. Additionally, nanofiber formulations demonstrated enhanced healing efficacy over cream formulations.

trial registrationThis trial was retrospectively registered by Iranian Registry of Clinical Trials (IRCT) at 14/11/2023. TRIAL REGISTRATION NUMBER: IRCT20230926059521N1.

Indexed as

AcyclovirAntiviral AgentsClobetasolHerpes LabialisNanofibersAdultFemaleHumansMaleMiddle AgedRecurrenceRetrospective StudiesTreatment OutcomeYoung AdultAcyclovirAntiviral AgentsClobetasolAcyclovirClobetasolHerpes labialisHerpes simplexNano

Identifiers

PMID39506756
PMCPMC11539845

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.