Evidence map›Paper›PMID 39507247›Full record

ArticleiScience2024

A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice.

Florence Mehl, Ana Rodríguez Sánchez-Archidona, Ida Meitil, Mathias Gerl, Céline Cruciani-Guglielmacci, Leonore Wigger, Hervé Le Stunff, Kelly Meneyrol, Justine Lallement, Jessica Denom and 6 more

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In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Florence MehlVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.
Ana Rodríguez Sánchez-ArchidonaVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.
Ida MeitilVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.
Mathias GerlLipotype GmbH, Dresden, Germany.
Céline Cruciani-GuglielmacciUniversité de Paris Cité, BFA, UMR 8251, CNRS, 75013 Paris, France.
Leonore WiggerVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.
Hervé Le StunffUniversité de Paris Cité, BFA, UMR 8251, CNRS, 75013 Paris, France.
Kelly MeneyrolUniversité de Paris Cité, BFA, UMR 8251, CNRS, 75013 Paris, France.
Justine LallementUniversité de Paris Cité, BFA, UMR 8251, CNRS, 75013 Paris, France.
Jessica DenomUniversité de Paris Cité, BFA, UMR 8251, CNRS, 75013 Paris, France.
Christian KloseLipotype GmbH, Dresden, Germany.
Kai SimonsLipotype GmbH, Dresden, Germany.
Marco PagniVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.
Christophe MagnanUniversité de Paris Cité, BFA, UMR 8251, CNRS, 75013 Paris, France.
Mark IbbersonVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.
Bernard ThorensVital-IT Group, SIB Swiss Institute for Bioinformatics, 1015 Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To identify the pathways that are coordinately regulated in pancreatic β cells, muscle, liver, and fat to control fasting glycemia we fed C57Bl/6, DBA/2, and Balb/c mice a regular chow or a high fat diet for 5, 13, and 33 days. Physiological, transcriptomic and lipidomic data were used in a data fusion approach to identify organ-specific pathways linked to fasting glycemia across all conditions investigated. In pancreatic islets, constant insulinemia despite higher glycemic levels was associated with reduced expression of hormone and neurotransmitter receptors, OXPHOS, cadherins, integrins, and gap junction mRNAs. Higher glycemia and insulin resistance were associated, in muscle, with decreased insulin signaling, glycolytic, Krebs' cycle, OXPHOS, and endo/exocytosis mRNAs; in hepatocytes, with reduced insulin signaling, branched chain amino acid catabolism and OXPHOS mRNAs; in adipose tissue, with increased innate immunity and lipid catabolism mRNAs. These data provide a resource for further studies of interorgan communication in glucose homeostasis.

Indexed as

BioinformaticsOmicsPhysiologyTranscriptomics

Identifiers

PMID39507247
PMCPMC11539597

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.