Evidence map›Paper›PMID 39508575›Full record

Trial reportJournal of rehabilitation medicine2024

Efficacy observation of combined transcutaneous vagus nerve stimulation and transcranial direct current stimulation on gait in 169 subacute stroke patients.

Litong Wang, Likai Wang, Zhan Wang, Hongyu Zhao, Jingyi Wu, Fei Gao, Hong Tang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of rehabilitation medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Litong WangSchool of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China; Rehabilitation Medicine Department, The Second Hospital of Dalian Medical University, Dalian, China.
Likai WangRehabilitation Medicine Department, The Second Hospital of Dalian Medical University, Dalian, China.
Zhan WangRehabilitation Medicine Department, The Second Hospital of Dalian Medical University, Dalian, China.
Hongyu ZhaoLab of Intelligent System, School of Control and Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China.
Jingyi WuRehabilitation Medicine Department, The Second Hospital of Dalian Medical University, Dalian, China.
Fei GaoRehabilitation Medicine Department, The Second Hospital of Dalian Medical University, Dalian, China.
Hong TangSchool of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China. tanghong@dlut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the combined effect of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation on improving lower limb function in stroke patients.

designRandomized controlled trial. SUBJECTS/PATIENTS: Subacute stroke patients.

methods169 post-stroke hemiplegia patients were randomly divided into 4 groups (control, transcranial direct current stimulation, transcutaneous auricular vagus nerve stimulation, and transcutaneous auricular vagus nerve stimulation combined with transcranial direct current stimulation) and evaluated using the Fugl-Meyer Assessment-Lower Extremity (FMA-LL), Timed Up-and-Go (TUG) test, Modified Barthel Index (MBI), Berg Balance Scale (BBS), gait parameters, and surface electromyography (sEMG).

resultsSignificant improvements in FMA-LL, MBI, BBS, TUG, gait parameters, and sEMG were noted in the intervention groups compared with the control, with the transcutaneous auricular vagus nerve stimulation combined with transcranial direct current stimulation group showing the most pronounced improvements. Differences in some outcomes were also notable between the transcutaneous auricular vagus nerve stimulation and transcranial direct current stimulation groups.

conclusionThe combination of transcutaneous auricular vagus nerve stimulation and transcranial direct current stimulation effectively enhances gait, balance, and daily living activities in subacute stroke patients. These benefits are likely due to transcutaneous auricular vagus nerve stimulation activating the solitary and trigeminal nuclei and transcranial direct current stimulation stimulating the motor cortex. Wearable gait analysis systems and electromyography are valuable in clinical gait assessment for these patients.

Indexed as

StrokeStroke RehabilitationTranscranial Direct Current StimulationTranscutaneous Electric Nerve StimulationVagus Nerve StimulationAdultAgedCombined Modality TherapyElectromyographyFemaleGaitHemiplegiaHumansMaleMiddle AgedTreatment Outcome

Identifiers

PMID39508575
PMCPMC11558862

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.