Evidence map›Paper›PMID 39509056›Full record

ReviewHeart failure reviews2025

The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined.

Haoran Jiang, Veraprapas Kittipibul, Felix Mahfoud, Michael Böhm, Paul A Sobotka, Murray Esler, Jie Wang, Marat Fudim

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Renal denervation alleviates neuroinflammation by suppressing the microglial Ifi27l2a/cGAS-STING signaling axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haoran JiangDuke University School of Medicine, Durham, NC, USA.
Veraprapas KittipibulDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Felix MahfoudDepartment of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland.
Michael BöhmDepartment of Internal Medicine III - Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Saarland University, Homburg, Germany.
Paul A SobotkaDepartment of Cardiology, The Ohio State University College of Medicine, Columbus, OH, USA.
Murray EslerBaker IDI Heart and Diabetes Institute, Melbourne, Australia.
Jie WangThe First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Marat FudimDepartment of Medicine, Duke University Medical Center, Durham, NC, USA. marat.fudim@duke.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interruption of sympathetic nerves connecting the kidney and the sympathetic nervous system can reduce blood pressure. Here, we present a review on how renal denervation can help hypertension patients, specifically focusing on our novel understanding of renal nerve anatomy, denervation technique, and subsequent clinical trials, and how it may be used to treat other cardiovascular diseases like heart failure.

Indexed as

Heart FailureHypertensionKidneySympathectomySympathetic Nervous SystemBlood PressureHumansHeart failureHypertensionRenal denervationRenal nerves

Identifiers

PMID39509056

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.