Evidence map›Paper›PMID 39509387›Full record

Trial reportPloS one2024

Triglyceride-glucose index (TyG index) is associated with a higher risk of colorectal adenoma and multiple adenomas in asymptomatic subjects.

Ziyue Zhu, Thomas Yuen Tung Lam, Raymond Shing Yan Tang, Sunny Hei Wong, Rashid Nok Shun Lui, Simon Siu Man Ng, Samuel Yeung Shan Wong, Joseph Jao Yiu Sung

2 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03597204 naactive not recruitingnot on this map

Colorectal Cancer (CRC) Screening in Hong Kong: an Analysis on Acceptability, Compliance, Diagnostic Accuracy and Clinical Outcomes

TypeinterventionalSponsorChinese University of Hong KongRan2015 to 2025Enrolled15,000ConditionsColorectal CancerArmsFecal immunochemical test (FIT), Colonoscopy
NCT04034953 naunknown statusnot on this map

Prevention of Obesity-related Cancers: Setting up of a Multi-Cancer Education and Prevention Program in Hong Kong

TypeinterventionalSponsorChinese University of Hong KongRan2018 to 2023Enrolled10,000ConditionsObesity, Colorectal Cancer, Prostate Cancer, Breast CancerArmsFaecal Immunochemical Test, Prostate-Specific Antigen Test, Mammogram
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziyue ZhuStanley Ho Big Data Decision Analytics Research Centre, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.ORCID 0000-0002-8797-7492
Thomas Yuen Tung LamThe Nethersole School of Nursing, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.ORCID 0000-0002-4306-4990
Raymond Shing Yan TangInstitute of Digestive Disease, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
Sunny Hei WongLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Rashid Nok Shun LuiInstitute of Digestive Disease, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
Simon Siu Man NgInstitute of Digestive Disease, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
Samuel Yeung Shan WongThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
Joseph Jao Yiu SungLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

hypothesisThe objective of this study is to evaluate the predictive ability of the TyG index for the presence of adenoma and multiple adenomas in an asymptomatic population.

designA secondary analysis was conducted on a prospective cohort of asymptomatic subjects aged between 50 and 75 who underwent CRC screening. Fasting blood glucose (FBG) and lipid profiles were measured within three months prior colonoscopy. TyG index was estimated as ln [fasting triglycerides (mg/dL) × FBG (mg/dL)/2]. Multivariate logistic regression was performed to assess the association between the TyG index and the risk of adenoma. Its association with multiple adenomas (≥5) and the continuous number of adenomas were assessed by multinomial regression and log-normal linear regression, respectively.

resultsA total of 1,538 subjects were recruited among which 876 subjects (57%) had at least one adenoma detected. Elevated TyG index was positively associated with the incidence of adenoma (adjusted odds ratio [aOR]: 1.26, 95% confidence interval [CI]: 1.04-1.54). Compared with the lowest TyG index (≤ 8) group, the risk of adenoma was the highest among subjects in the highest TyG index (> 10) group (aOR: 3.36, 95% CI: 1.44-7.73). As compared to the non-adenoma group, the TyG index was also positively associated with multiple adenomas (aOR: 1.74, 95% CI: 1.17-2.57), and the estimate was also the highest in the highest TyG group (aOR: 14.49, 95% CI: 3.12-67.20). As for the number of adenomas, the positive association was maintained (Estimates: 1.06, 95% CI: 1.01-1.12) while the number of adenomas increase the most in the highest TyG index group (Estimates: 1.35, 95% CI: 1.10-1.65).

conclusionsElevated TyG index is associated with an increased risk of colorectal adenoma and an increased number of adenomas for asymptomatic subjects aged ≥50.

trial registrationThis study was registered on clinicaltrials.gov (NCT03597204 and NCT04034953).

Indexed as

AdenomaBlood GlucoseColorectal NeoplasmsTriglyceridesAgedColonoscopyFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsBlood GlucoseTriglycerides

Identifiers

PMID39509387
PMCPMC11542827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.