Evidence mapPaperPMID 39509583Full record

ArticlePharmacology research & perspectives2024

Favipiravir pharmacokinetics in Thai adults with mild COVID-19: A sub-study of interpatient variability and ethnic differences in exposure.

Ing-Orn Prasanchaimontri, Weerawat Manosuthi, Henry Pertinez, Andrew Owen, Suvimol Niyomnaitham, Rujipas Sirijatuphat, Lantharita Charoenpong, Tim R Cressey, Katherine Copeland, Phongpan Mokmued and 1 more

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ing-Orn PrasanchaimontriBureau of Drug and Narcotic, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.ORCID 0009-0008-9873-6142
Weerawat ManosuthiBamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.ORCID 0000-0003-2583-9390
Henry PertinezDepartment of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK.
Andrew OwenDepartment of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK.ORCID 0000-0002-9819-7651
Suvimol NiyomnaithamDepartment of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand.ORCID 0000-0002-4785-2716
Rujipas SirijatuphatDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand.ORCID 0000-0003-1486-5550
Lantharita CharoenpongBamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.ORCID 0000-0003-3811-0267
Tim R CresseyAMS-PHPT Research Collaboration, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0002-8106-0974
Katherine CopelandSiriraj Institute of Clinical Research (SICRES), Mahidol University, Nakhon Pathom, Thailand.ORCID 0009-0004-8609-8041
Phongpan MokmuedMedical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.ORCID 0000-0002-9361-2668
Kulkanya ChokephaibulkitSiriraj Institute of Clinical Research (SICRES), Mahidol University, Nakhon Pathom, Thailand.ORCID 0000-0002-0140-4600

Funding

The Long-Acting/Extended Release Antiretroviral Resource Program (LEAP)R24AI118397 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$1.2M
National Research Council of Thailand 63-088NIH HHS R01AI134091NIH HHS R24AI118397Siriraj Research and Development Fund (IO) R016434001
6 · The paper itself

Abstract

This sub-study sought to characterize the pharmacokinetics (PK) of favipiravir (FPV) within Thai adults and quantitatively assess differences in exposure to those previously reported in other populations as a basis to understand putative differences in efficacy between studies conducted in different regions. It was nested within a prospective trial of adults with symptomatic COVID-19 infection without pneumonia receiving 1800 mg FPV twice-daily on day 1 and 800 mg twice-daily thereafter. Individual PK profiles were fitted with a one-compartment disposition model (first-order absorption). Eight adults (seven female) with a median age of 39 years and BMI of 27.9 kg/m

Indexed as

AmidesAntiviral AgentsCOVID-19 Drug TreatmentPyrazinesAdultCOVID-19EthnicityFemaleHumansMaleMiddle AgedProspective StudiesSoutheast Asian PeopleThailandAmidesAntiviral AgentsfavipiravirPyrazinesadultCOVID‐19drug modelingfavipiravirpharmacokineticsThailand

Identifiers

PMID39509583
PMCPMC11542727

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.