ArticleAmerican journal of surgery2025
Female patients exhibit altered vasopressin-induced coronary microvascular contractile response and molecular signaling following cardiac surgery.
Article in American journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
backgroundEmerging data suggest women have worse outcomes than men following cardioplegia and cardiopulmonary bypass (CP/CPB). Altered coronary microvascular function affecting myocardial perfusion may contribute, but human translational studies are lacking.
methodsViable coronary microvessels (<200 μ m) were dissected from human atrial samples collected before and after CP/CPB from a subset of 108 patients enrolled. Ex vivo contractile responses to vasopressin were assessed using video microscopy. RNA deep-sequencing and immunoblotting were used to quantify gene and protein expression, respectively.
resultsCoronary microvessels exhibited increased vasopressin-induced contractile responses post-CP/CPB in males and females (p < 0.0001). Females exhibited a decrease in microvascular contractile response versus males pre- (p = 0.1) and post-CP/CPB (p = 0.09) which approached significance. Myocardial vasopressin 1a receptor levels were increased in females versus males (p = 0.001). Vasopressin-induced vasoconstriction predicted postoperative cardiac index.
conclusionsImpaired coronary microvascular contractile responses in females jeopardizing myocardial perfusion may underlie worse outcomes following cardiac surgery.
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