Evidence map›Paper›PMID 39509964›Full record

ReviewCurrent opinion in genetics & development2024

Engineering immune organoids to regenerate host immune system.

Sefali Patel, Wen Liu, Ravikumar K, Catherine McCormick, Yong Fan

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sefali PatelAHN Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Wen LiuAHN Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Ravikumar KDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Catherine McCormickAHN Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Yong FanAHN Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: Yong.Fan@Ahn.Org.

Funding

Induction of allogeneic tolerance with bioengineered thymus organoidsR01AI123392 · NIAID · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI FAN, YONG · 2016 to 2019
$1.5M
Novel hematopoietic humanized mouse model to study CAR-T therapy-associated cytokine release syndromeR21OD034476 · OD · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI FAN, YONG · 2023 to 2024
$445k
Rejuvenate aged adaptive immunity with bioengineered thymus organoidsR21AI126335 · NIAID · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI FAN, YONG · 2016 to 2017
$430k
NIAID NIH HHS R01 AI123392NIAID NIH HHS R21 AI126335NIH HHS R21 OD034476
6 · The paper itself

Abstract

Recent advances in immunotherapy have underscored the potential of harnessing the immune system to treat disorders associated with immune dysregulation, such as primary and secondary immunodeficiencies, cancer, transplantation rejection, and aging. Owing to the cellular and structural complexity and the dynamic nature of immune responses, engineering immune organoids that replicate the function and key features of their corresponding immune organs continues to be a formidable challenge. In this overview, we will discuss the recent progress in bioengineering organoids of key primary and secondary immune organs and tissues, focusing particularly on their contributions to the host's immune system in animal models and highlighting their potential roles in regenerative medicine.

Indexed as

Immune SystemOrganoidsRegenerative MedicineAnimalsBioengineeringHumansImmunotherapyRegenerationTissue Engineering

Identifiers

PMID39509964
PMCPMC11588509

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.