Evidence map›Paper›PMID 39513868›Full record

ArticleCells2024

Prominin-1 Knockdown Causes RPE Degeneration in a Mouse Model.

Sujoy Bhattacharya, Tzushan Sharon Yang, Bretton P Nabit, Evan S Krystofiak, Tonia S Rex, Edward Chaum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sujoy BhattacharyaDepartment of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-4443-9691
Tzushan Sharon YangPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Bretton P NabitPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Evan S KrystofiakCell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Tonia S RexDepartment of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Edward ChaumDepartment of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-3542-8376

Funding

Conventional 200 keV Transmission Electron MicroscopeS10OD034315 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEROME, WALTER G · 2023 to 2023
$597k
International Retina Research Foundation, the Potocsnak family gift to the Vanderbilt Eye Institute, the Margy Ann and J Donald M Gass Chair endowment, and an unrestricted departmental research grant from Research to Prevent Blindness, Inc (New York, NY). P30CA068485, S10OD023475-01A1, S10 OD016355, IS1BX003154, CA68485, DK20593, DK58404, DK59637, EY08126, and 1S100D034315-01.NIH HHS S10 OD034315
6 · The paper itself

Abstract

There are currently no effective treatments for retinal pigment epithelial (RPE) cell loss in atrophic AMD (aAMD). However, our research on

Indexed as

AC133 AntigenGeographic AtrophyRetinal Pigment EpitheliumAnimalsDisease Models, AnimalFemaleGene Knockdown TechniquesHomeostasisHumansMaleMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ImmunoelectronPhotoreceptor Cells, VertebrateSingle-Cell Gene Expression AnalysisAC133 AntigenPROM1 protein, humanProm1 protein, mouseadeno-associated virus (AAV2/1)atrophic age-related macular degenerationgeographic atrophylysosomal pathwaysmicrogliamitochondria

Identifiers

PMID39513868
PMCPMC11545618

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.