Evidence map›Paper›PMID 39513882›Full record

ArticleCells2024

Reduced T and NK Cell Activity in Glioblastoma Patients Correlates with TIM-3 and BAT3 Dysregulation.

Farah Ahmady, Peter Curpen, Louis Perriman, Adilson Fonseca Teixeira, Siqi Wu, Hong-Jian Zhu, Arpita Poddar, Aparna Jayachandran, George Kannourakis, Rodney B Luwor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farah AhmadyFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.
Peter CurpenTownsville Hospital and Health Service, James Cook University, Townsville, QLD 4814, Australia.ORCID 0009-0003-5381-9933
Louis PerrimanFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.ORCID 0009-0005-7949-8597
Adilson Fonseca TeixeiraDepartment of Surgery, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia.
Siqi WuDepartment of Surgery, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia.ORCID 0000-0001-8234-6600
Hong-Jian ZhuDepartment of Surgery, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia.
Arpita PoddarFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.
Aparna JayachandranFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.
George KannourakisFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.
Rodney B LuworFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.ORCID 0000-0002-3020-4245

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibitory receptors are critical for regulating immune cell function. In cancer, these receptors are often over-expressed on the cell surface of T and NK cells, leading to reduced anti-tumor activity. Here, through the analysis of 11 commonly studied checkpoint and inhibitory receptors, we discern that only

Indexed as

GlioblastomaHepatitis A Virus Cellular Receptor 2Killer Cells, NaturalAntigens, CDBrain NeoplasmsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGene Expression Regulation, NeoplasticHumansInterferon-gammaLectins, C-TypeLymphocyte ActivationMaleMiddle AgedMolecular ChaperonesAntigens, CDBAG6 protein, humanHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Interferon-gammaLectins, C-TypeMolecular ChaperonesBAT3glioblastomaT cell exhaustionTIM-3

Identifiers

PMID39513882
PMCPMC11545661

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.