Evidence map›Paper›PMID 39514052›Full record

ReviewAdvances in experimental medicine and biology2025

Amniotic Membrane Transplantation: Clinical Applications in Enhancing Wound Healing and Tissue Regeneration.

Mutali Musa, Ekele Chukwuyem, Ehimare Enaholo, Ifeoma Esekea, Eghosasere Iyamu, Fabiana D'Esposito, Daniele Tognetto, Caterina Gagliano, Marco Zeppieri

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mutali MusaDepartment of Optometry, University of Benin, Benin City, Nigeria.ORCID https://orcid.org/0000-0001-7486-8361
Ekele ChukwuyemDepartment of Ophthalmology, Centre for Sight Africa, Nkpor, Nigeria.ORCID https://orcid.org/0000-0003-4831-5389
Ehimare EnaholoDepartment of Ophthalmology, Centre for Sight Africa, Nkpor, Nigeria.ORCID https://orcid.org/0000-0002-2410-7510
Ifeoma EsekeaDepartment of Optometry, University of Benin, Benin City, Nigeria.ORCID https://orcid.org/0009-0008-8811-7081
Eghosasere IyamuDepartment of Optometry, University of Benin, Benin City, Nigeria.ORCID https://orcid.org/0000-0002-1833-3175
Fabiana D'EspositoImperial College Ophthalmic Research Group (ICORG) Unit, Imperial College, London, UK.ORCID https://orcid.org/0000-0002-7938-876X
Daniele TognettoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0001-7197-7765
Caterina GaglianoDepartment of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, Enna, Italy.ORCID https://orcid.org/0000-0001-8424-0068
Marco ZeppieriDepartment of Ophthalmology, University Hospital of Udine, Udine, Italy. mark.zeppieri@asufc.sanita.fvg.it.ORCID https://orcid.org/0000-0003-0999-5545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds and non-healing tissue defects pose significant clinical challenges, necessitating innovative therapeutic approaches. A comprehensive literature review of amniotic membrane transplantation for wound healing and tissue repair evaluates the efficacy and safety of amniotic membrane transplantation in enhancing wound healing and tissue repair. Amniotic membranes promote wound closure and reduce inflammation and scarring via abundant growth factors, cytokines, and extracellular matrix components, which foster conducive environments for tissue regeneration. Amniotic membrane transplantation is effective in various medical disciplines, including ophthalmology, dermatology, and orthopedics. Low immunogenicity and anti-microbial properties ensure their safe application. Amniotic membrane transplantation offers a promising therapeutic approach for wound healing and tissue repair, and further research is warranted to explore its regenerative potential fully.

Indexed as

AmnionRegenerationWound HealingAnimalsHumansAmniotic membrane transplantationRegenerative medicineTissue repairWound healing

Identifiers

PMID39514052

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.