Evidence map›Paper›PMID 39516519›Full record

ArticleScientific reports2024

Right hemisphere stroke is linked to reduced social connectedness in the UK Biobank cohort.

Katherine O'Connell, Abigail A Marsh, Anna Seydell-Greenwald

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katherine O'ConnellInterdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, 20057, USA. kmo52@georgetown.edu.
Abigail A MarshDepartment of Psychology, Georgetown University, Washington, DC, 20057, USA.
Anna Seydell-GreenwaldCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington, DC, 20057, USA.

Funding

Translational Biomedical Science Training GrantTL1TR001431 · NCATS · GEORGETOWN UNIVERSITY · PI LEE, DEXTER L, SANDBERG, KATHRYN L · 2015 to 2024
$4.8M
Visuospatial deficits after stroke: Towards better classification, diagnostics, and rehabilitation.R01HD105735 · NICHD · GEORGETOWN UNIVERSITY · PI Anna Greenwald · 2022 to 2026
$2.1M
Rehabilitation for emotion recognition impairments after stroke: building a scientific basisR21HD095273 · NICHD · GEORGETOWN UNIVERSITY · PI GREENWALD, ANNA · 2018 to 2019
$437k
Evaluating the impact of a social meditation training on acute pain experienceF31AT010423 · NCCIH · GEORGETOWN UNIVERSITY · PI O'CONNELL, KATHERINE · 2020 to 2021
$66k
NCATS NIH HHS TL1 TR001431NCCIH NIH HHS F31 AT010423NICHD NIH HHS R01 HD105735NICHD NIH HHS R21 HD095273NIH HHS R01HD105735NIH HHS TL1TR001431
6 · The paper itself

Abstract

Social connectedness is fundamental to health and life satisfaction. Empathic capacities that support social connections are commonly impaired following damage to the brain's right hemisphere, but how these acquired socio-emotional deficits correspond to real-world social outcomes remains unclear. Using anatomical brain imaging and behavioral data from a large sample of stroke survivors included in the UK Biobank (n = 209), we link damage to regions of the right hemisphere involved in emotion recognition to lower social relationship satisfaction and higher loneliness. The effect was driven by lesions to the right anterior insula and not explained by stroke extent and motor function; it was further corroborated by an exploratory analysis of social decline in a few participants for whom data were available from before and after a stroke to the right anterior insula (n = 3; comparison n = 13). These correlational findings provide new insight into the role of the right hemisphere in maintaining social connections and bear important implications for treatment and rehabilitation post-stroke.

Indexed as

StrokeAgedBiological Specimen BanksCohort StudiesFemaleHumansInsular CortexLonelinessMagnetic Resonance ImagingMaleMiddle AgedUK BiobankUnited KingdomAnterior insulaBrain imagingMRISocial activitySocial connectednessStrokeUK Biobank

Identifiers

PMID39516519
PMCPMC11549225

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.