ArticleThe journal of headache and pain2024
Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache.
Article in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mapping the immune and epigenetic landscape of medication-overuse headache (MOH): a systematic review.Frontiers in immunology · 2026Pooled it
- Unravelling the gut-brain connection: a systematic review of migraine and the gut microbiome.The journal of headache and pain · 2025Pooled it
- IgG positive food elimination diet altered gut microbiota, decreased zonulin in migraine adults: a pilot dietary intervention trial.Frontiers in nutrition · 2026Trial
- tVNS Mitigates Neuroinflammation and Nociception in a Rodent LPS Endotoxemia Model.Clinical and translational science · 2026Article
- Breaking the medication overuse headache cycle: from nociplastic pain mechanisms to patient-centered interventions - the Junior Editorial Board vision.The journal of headache and pain · 2026Review
- Mechanistic investigation of HMGB1 in an in vitro model of the trigeminovascular system under migraine-like conditions.The journal of headache and pain · 2026Article
- Gut microbiota dysbiosis and metabolic reprogramming in pediatric migraine: a multi-omics analysis revealing diagnostic biomarkers.The journal of headache and pain · 2026Article
- Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms.Journal of clinical medicine · 2026Review
- Altered serum short-chain fatty acid profiles in episodic and chronic migraine and their modulation by preventive treatment.The journal of headache and pain · 2026Article
- The microgenderome in migraine: integrating sex hormones, microbial composition, and metabolic profiles into a sex-related framework.Frontiers in microbiology · 2026Review
- A review on gut microbiota and migraine severity: a complex relationship.Inflammopharmacology · 2026Review
- The effect of short-term consumption ofExperimental biology and medicine (Maywood, N.J.) · 2026Article
- Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse Headache: A Cross-sectional Study.Brain and behavior · 2025Article
- Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache.Brain and behavior · 2025Article
- Oral and Gut Dysbiosis in Migraine: Oral Microbial Signatures as Biomarkers of Migraine.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Dissecting Causal Relationships Between Gut Microbiota, Immunocyte Phenotype, and Migraine: A Mendelian Randomization Study.Brain and behavior · 2025Article
- The Gut Microbiome and Migraine: Updates in Understanding.Current neurology and neuroscience reports · 2025Review
- The Interplay Between Gut Microbiota, Adipose Tissue, and Migraine: A Narrative Review.Nutrients · 2025Review
- Critical reflections on medication overuse headache in patients with migraine: An unsolved riddle in nociception.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveChronic migraine (CM) patients with medication overuse headache (MOH) were recently shown to be associated with leaky gut and inflammation. We aimed to investigate gut microbiota profiles of CM patients with MOH, and their correlations with inflammatory serum parameters, migraine food triggers, and comorbid anxiety and depression. MATERIALS AND
methodsThe study included women participants (32 CM patients with NSAID overuse headache, and 16 healthy non-headache sufferers). Migraine duration, monthly migraine headache days, presence of irritable bowel syndrome symptoms, and HADS-D and HADS-A scores were recorded. Serum samples were collected to measure circulating LPS, HMGB1, HIF-1α, and IL-6. The gut microbiota profiles of the patients were evaluated using fecal samples.
resultsSerum LPS, HMGB1, HIF-1α, and IL-6 levels were significantly higher in the CM + MOH group compared to the healthy controls. HADS-A and HADS-D scores were considerably higher in the CM + MOH group compared to the healthy controls. In the microbiota analysis, alpha and beta diversities were similar between the two groups. The class Clostridia, the order Eubacteriales, and the genus Ruminococcus were less abundant in the CM + NSAID overuse headache group compared to the control group. At the genus level Desulfovibrio, Gemmiger, and Dialister and at the species level, Clostridium fessum, Blautia luti, Dorea longicatena, Eubacterium coprostanoligenes, and Gemmiger formicilis were more abundant in the CM + NSAID overuse headache group compared to the control group. Desulfovibrio, Gemmiger, Dialister, Ethanoligenens harbinense, Eubacterium coprostanoligenes, Dorea longicatena, and Thermoclostridium stercorarium showed positive correlations and Clostridia bacteria showed negative correlations with migraine food triggers. Positive correlations were found between LPS and Hapalosiphonaceae, HMGB1 and Melghirimyces, HIF1-α and Rouxeilla and Blautia luti, IL-6 and Melghirimyces and Ruminococcus.
conclusionIn CM patients with MOH, we have revealed the presence of dysbiosis towards an inflammatory state, and positive correlations were shown between altered gut microbiota and inflammatory serum parameters and migraine food triggers.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.