Evidence map›Paper›PMID 39518997›Full record

ArticleInternational journal of molecular sciences2024

Phenotype in Individuals with Heterozygous Rare Variants in

Erin O Jacob, Jian Wang, Adam D McIntyre, Robert A Hegele

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Patterns of lipid profile and genetic variations in South Asians.Cardiovascular diabetology. Endocrinology reports · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erin O JacobRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 4288A-1151 Richmond Street, London, ON N6A 5B7, Canada.
Jian WangRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 4288A-1151 Richmond Street, London, ON N6A 5B7, Canada.ORCID 0000-0002-6759-0522
Adam D McIntyreRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 4288A-1151 Richmond Street, London, ON N6A 5B7, Canada.ORCID 0000-0002-7836-5187
Robert A HegeleRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 4288A-1151 Richmond Street, London, ON N6A 5B7, Canada.ORCID 0000-0003-2861-5325

Funding

Heart and Stroke Foundation G-21-0031455
6 · The paper itself

Abstract

Hepatic lipase deficiency is a rare genetic condition caused by biallelic loss-of-function variants in the

Indexed as

HeterozygoteLipasePhenotypeAdolescentAdultCholesterol, HDLCholesterol, LDLFemaleHumansMaleMiddle AgedRetrospective StudiesTriglyceridesYoung AdultCholesterol, HDLCholesterol, LDLLipaseLIPC protein, humanTriglyceridesbioinformaticsdyslipidemiahepatic lipasehepatic lipase deficiencyhypercholesterolemiaLIPC gene variantnext-generation DNA sequencingpathogenic variantrecessive

Identifiers

PMID39518997
PMCPMC11546775

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.