Evidence map›Paper›PMID 39519127›Full record

ArticleInternational journal of molecular sciences2024

Restoring Colistin Sensitivity in Multidrug-Resistant Pathogenic

Chenchen Wang, Ziyi Zhang, Di Liu, Xiaodan Li, Zhaoran Zhang, Yan Zeng, Wenqi Dong, Chen Tan, Manli Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Public health challenges · 2026
    Review
  3. Exploring multiple drug actions of a CaNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenchen WangHubei Biopesticide Engineering Research Centre, Wuhan 430000, China.
Ziyi ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Di LiuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Xiaodan LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Zhaoran ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Yan ZengCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Wenqi DongCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Chen TanCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China.
Manli LiuHubei Biopesticide Engineering Research Centre, Wuhan 430000, China.ORCID 0009-0005-8623-3087

Funding

Hubei Agricultural Science Technology Innovation Center 2021-620-000-001-027National Key Research and Development Program 2021YFD1800402
6 · The paper itself

Abstract

Restoring colistin's efficacy is crucial in addressing the resistance crisis of colistin. This study utilized a high-throughput screening method to identify 43 compounds from 800 FDA-approved drugs that exhibited significant antibacterial effects when combined with colistin. Among these, cinacalcet hydrochloride (CH) was selected for its potential synergistic effect with colistin against multidrug-resistant (MDR)

Indexed as

Anti-Bacterial AgentsBiofilmsCinacalcetColistinDrug Resistance, Multiple, BacterialDrug SynergismEscherichia coliMicrobial Sensitivity TestsAnimalsEscherichia coli InfectionsEscherichia coli ProteinsHumansMiceAnti-Bacterial AgentsCinacalcetColistinEscherichia coli Proteinsantibacterialcinacalcet hydrochloridecolistincombination therapymcr-1

Identifiers

PMID39519127
PMCPMC11546906

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.