Evidence map›Paper›PMID 39519513›Full record

ArticleNutrients2024

Circulating Phylloquinone and the Risk of Four Female-Specific Cancers: A Mendelian Randomization Study.

Melaku Yalew, Anwar Mulugeta, Amanda L Lumsden, Iqbal Madakkatel, S Hong Lee, Martin K Oehler, Johanna Mäenpää, Elina Hyppönen

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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melaku YalewAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0002-7314-2523
Anwar MulugetaAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0002-8018-3454
Amanda L LumsdenAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0002-0214-6498
Iqbal MadakkatelAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0003-2339-5917
S Hong LeeAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0001-9701-2718
Martin K OehlerDepartment of Gynecological Oncology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Johanna MäenpääFaculty of Medicine and Medical Technology, Tampere University, 33014 Tampere, Finland.
Elina HyppönenAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0003-3670-9399

Funding

Medical Research Future Fund of Australia 2007431
6 · The paper itself

Abstract

backgroundObservational studies have linked vitamin K and cancer, but the causality of this association remains unknown. This Mendelian randomization (MR) study aims to investigate the association between circulating phylloquinone (vitamin K

methodsWe used four single-nucleotide polymorphisms (SNPs) to instrument phylloquinone, with the reported F-statistic 16.00-28.44 for all variants. SNP-outcome associations were obtained from consortia meta-analyses, UK Biobank, and the FinnGen database (up to 145,257/419,675, 27,446/362,324, 15,181/591,477, and 2211/320,454 cases/controls for breast, ovarian, endometrial, and cervical cancer, respectively). Analyses were conducted using five complementary MR methods including pleiotropy robust approaches. The MR Egger intercept test, MR PRESSO global test and leave-one-out analyses were used to test for and identify pleiotropic variants.

resultsThe relevance of the instrument was validated by positive control analyses on coagulation factor IX (

conclusionsWe found no evidence for an association between genetically predicted circulating phylloquinone levels and the risk of four female-specific cancers.

Indexed as

Mendelian Randomization AnalysisPolymorphism, Single NucleotideVitamin K 1Breast NeoplasmsEndometrial NeoplasmsFemaleGenetic Predisposition to DiseaseHumansOvarian NeoplasmsRisk FactorsVitamin K 1circulating phylloquinonefemale-specific cancersMendelian randomizationvitamin K1

Identifiers

PMID39519513
PMCPMC11547380

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.