Evidence map›Paper›PMID 39519557›Full record

ReviewNutrients2024

Associations of Maternal Nutritional Status and Supplementation with Fetal, Newborn, and Infant Outcomes in Low-Income and Middle-Income Settings: An Overview of Reviews.

Doris González-Fernández, Oviya Muralidharan, Paulo A Neves, Zulfiqar A Bhutta

Registry-linked trialAbstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07489664 (Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07489664 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat

TypeinterventionalSponsorAga Khan UniversityRan2026 to 2028Enrolled292ConditionsHeat Stress, Pregnancy, Women of Reproductive Age, Nutrition StatusArmsIndigenous Balanced Diet Arm
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of Maternal Vitamin BCurrent nutrition reports · 2025
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Doris González-FernándezCentre for Global Child Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Oviya MuralidharanCentre for Global Child Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-5214-6103
Paulo A NevesCentre for Global Child Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-1200-4725
Zulfiqar A BhuttaCentre for Global Child Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-0637-599X

Funding

Bill and Melinda Gates Foundation INV-058017
6 · The paper itself

Abstract

BACKGROUND/

objectivesDespite advances in maternal nutritional knowledge, the effect of maternal diet, micronutrient status and undernutrition, and the effect of maternal supplementation on fetal, neonatal and infant outcomes still have gaps in the literature. This overview of reviews is intended to assess the available information on these issues and identify the main maternal nutritional factors associated with offspring outcomes in low- and middle-income countries as possible targets for public health interventions.

methodsThe literature search was performed in Medline (PubMed) and Cochrane Library datasets in June 2024. Pre-specified outcomes in offspring were pooled using standard meta-analytical methods.

resultsWe found consistent evidence on the impact of maternal undernutrition indicated by low body mass index (BMI), mid-upper arm circumference (MUAC), and stature, but not of individual micronutrient status, on intrauterine-growth retardation, preterm birth, low birth weight, and small for gestational age, with research showing a possible effect of maternal undernutrition in later child nutritional status. Studies on micronutrient supplementation showed possible beneficial effects of iron, vitamin D, and multiple micronutrients on birthweight and/or decreasing small for gestational age, as well as a possible effect of calcium on preterm birth reduction. Interventions showing more consistent beneficial outcomes were balanced protein-energy and lipid base supplements, which demonstrated improved weight in newborns from supplemented mothers and a decreased risk of adverse neonatal outcomes.

conclusionsFurther research is needed to identify the benefits and risks of maternal individual micronutrient supplementation on neonatal and further child outcomes.

Indexed as

Dietary SupplementsMaternal Nutritional Physiological PhenomenaNutritional StatusDeveloping CountriesFemaleHumansInfantInfant, NewbornMalnutritionMicronutrientsPovertyPregnancyPremature BirthMicronutrientsintrauterine growth restrictionlow birthweightmaternal under-nutritionprenatal supplementationpreterm birthsmall for gestational age

Identifiers

PMID39519557
PMCPMC11547697

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.