ArticleMolecules (Basel, Switzerland)2024
Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2'-
Menny M Benjamin, George S Hanna, Cody F Dickinson, Yeun-Mun Choo, Xiaojuan Wang, Jessica A Downs-Bowen, Ramyani De, Tamara R McBrayer, Raymond F Schinazi, Sarah E Nielson and 9 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Menny M BenjaminDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, 280 Calhoun St, Charleston, SC 29425, USA.ORCID 0000-0002-0212-3405 George S HannaDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, 280 Calhoun St, Charleston, SC 29425, USA.ORCID 0000-0001-7616-064X Cody F DickinsonDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, 280 Calhoun St, Charleston, SC 29425, USA.ORCID 0000-0003-1318-4438 Jessica A Downs-BowenCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, HSRB-1, Atlanta, GA 30322, USA.ORCID 0000-0002-7472-033X Ramyani DeCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, HSRB-1, Atlanta, GA 30322, USA.ORCID 0000-0001-5534-0705 Tamara R McBrayerCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, HSRB-1, Atlanta, GA 30322, USA.
Raymond F SchinaziCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, HSRB-1, Atlanta, GA 30322, USA.ORCID 0000-0002-6688-3614 Pankaj PandeyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0001-9128-8254 Robert J DoerksenDepartment of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-3789-1842 Danyelle M TownsendDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St, DD410, Charleston, SC 29425, USA.ORCID 0000-0003-4679-1891 Jie ZhangDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St, DD410, Charleston, SC 29425, USA.
Zhiwei YeDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St, DD410, Charleston, SC 29425, USA.
Scott WyerDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, 280 Calhoun St, Charleston, SC 29425, USA.
Lucas BialousowDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, 280 Calhoun St, Charleston, SC 29425, USA.ORCID 0000-0003-1126-8670 Mark T HamannDepartment of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, 280 Calhoun St, Charleston, SC 29425, USA.
Funding
Synthesis and Optimization of the Aleutianamine Class of AlkaloidsR01GM145845 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HAMANN, MARK T, TIUS, MARCUS ANTONIUS · 2022 to 2025
$2.4MNatural Product HCV Drugs from Rare Plant-Microbe InteractionsR01AT007318 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI HAMANN, MARK T · 2012 to 2016
$1.6MNCCIH NIH HHS R01 AT007318NIGMS NIH HHS R01 GM145845NIH NIGMS R01 GM145845-01
6 · The paper itselfAbstract
The design and synthesis of antiviral compounds were guided by computationally predicted data against highly conserved non-structural proteins (Nsps) of the SARS-CoV-2 coronavirus. Chromenephenylmethanone-1 (CPM-1), a novel biphenylpyran (BPP), was selected from a unique natural product library based on in silico docking scores to coronavirus Nsps with high specificity to the methyltransferase protein (2'-
Indexed as
Antiviral AgentsMethyltransferasesMolecular Docking SimulationSARS-CoV-2Viral Nonstructural ProteinsCannabinoidsCOVID-19COVID-19 Drug TreatmentEnzyme InhibitorsHumansViral Regulatory and Accessory ProteinsAntiviral AgentsCannabinoidsEnzyme InhibitorsMethyltransferasesNSP16 protein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2Viral Nonstructural ProteinsViral Regulatory and Accessory Proteins2′-O-MTasecannabinoidcomputational screencoronavirusDP4+ NMR analysesin silicomethyltransferasenatural productsnon-structural proteinNspSARS-CoV-2
Identifiers
PMID39519722
PMCPMC11547505
What Socratic holds
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