ArticleThe international journal of neuropsychopharmacology2024
Anhedonia is associated with a specific depression profile and poor antidepressant response.
Article in The international journal of neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Positive Affect as a Transdiagnostic Target for Reducing Adolescent Depression & Suicide Risk: Do Mindfulness, Savoring, & Gratitude Help?Journal of adolescence · 2026Trial
- Improvements in health-related quality of life with esketamine nasal spray versus quetiapine extended release.European psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
- Higher Lipopolysaccharide Levels Are Linked to Less Anhedonia and Lower Severity of Major Depressive Disorder.Brain sciences · 2026Article
- Understanding Anticipatory Anhedonia in Schizophrenia and Depression: Linking Reward Representation Maintenance from a Transdiagnostic Perspective.Schizophrenia bulletin · 2026Article
- Peripheral immune-redox signatures associate with cortical network alterations in anhedonic depression.Molecular psychiatry · 2026Article
- On the relationships between apathy, depression and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Developing Clinically Interpretable Neuroimaging Biotypes in Psychiatry.Biological psychiatry · 2026Review
- Comparative multidimensional psychosocial profiles of major depressive disorder patients with higher versus lower anhedonia burden: a cross-sectional study.BMC psychiatry · 2026Article
- Dietary Patterns and Depressive Symptom Severity in the Hungarian Adult Population: Evidence from a Nationally Representative Survey.Nutrients · 2026Article
- Episode-wide Maudsley staging in treatment-resistant depression: a longitudinal tertiary-care comparison of dimensional and categorical outcomes.Frontiers in psychiatry · 2026Article
- Anhedonia nonresponse to short-term ketamine administration for treatment-resistant bipolar depression.Therapeutic advances in psychopharmacology · 2026Article
- Network and Factor Structure of Depression and Anxiety Symptoms in Telemental Healthcare Patients From Bangladesh: Evidence for Precision Mental Healthcare.Depression and anxiety · 2026Observational
- Which aspects of anhedonia predict response to pharmacotherapy in major depressive disorder?Psychological medicine · 2025Article
- Electroencephalogram Gamma Band Power Correlates with Anhedonia in a Community Sample.Journal of personalized medicine · 2025Article
- Unsolved Issues in Anhedonia: A Call for Targeted Inquiry.Actas espanolas de psiquiatria · 2025Article
- Clinical burden of major depressive disorder with versus without prominent anhedonia using a real-world electronic health records and claims linked database.BMC psychiatry · 2025Article
- Special Issue "Depression: From Molecular Basis to Therapy".International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundAnhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking. MATERIALS AND
methodsOne thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery-Åsberg Depression Rating Scale anhedonia item "inability to feel." Clinical and demographic features were then analyzed.
resultsThe presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive episodes, more severe MDD, and more frequent inpatient status). Furthermore, anhedonia was associated with nonresponse to treatment and treatment resistance, even after adjusting for confounding variables.
conclusionsOur findings support the role of anhedonia as a modulating feature of MDD, being associated with a more severe depression profile. Moreover, anhedonic features are independent predictors of poor treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.