Evidence map›Paper›PMID 39523005›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Bacteremia and Meningitis Caused by Penicillin-resistant Streptococcus pneumoniae Serotype 35B Successfully Treated with Ceftriaxone Combined with Vancomycin Followed by Linezolid.

Mifumi Tomioka, Kiwamu Nakamura, Shaoqing Duan, Kazuaki Matsumoto, Takahiro Shindo, Keisuke Hoshi, Mika Nagao, Fuminari Oshima, Yasuka Hara, Yoshiyuki Namai

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mifumi TomiokaDepartment of Pediatric, Ohta-Nishinouchi Hospital, Japan.
Kiwamu NakamuraLaboratory Medicine and Infectious Disease, Department of Internal Medicine, Iwate Medical University, Japan.
Shaoqing DuanDepartment of Pharmacology, Keio University, Japan.
Kazuaki MatsumotoDepartment of Pharmacology, Keio University, Japan.
Takahiro ShindoDepartment of Pediatric, Ohta-Nishinouchi Hospital, Japan.
Keisuke HoshiDepartment of Pediatric, Ohta-Nishinouchi Hospital, Japan.
Mika NagaoDepartment of Pediatric, Ohta-Nishinouchi Hospital, Japan.
Fuminari OshimaDepartment of Pharmacology, Ohta-Nishinouchi Hospital, Japan.
Yasuka HaraInfection Control Unit, Fukushima Medical University Hospital, Japan.
Yoshiyuki NamaiDepartment of Pediatric, Ohta-Nishinouchi Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of bacterial meningitis and bacteremia in a 3-month-old boy caused by Streptococcus pneumoniae serotype 35B multidrug resistance. Intravenous ampicillin was administered on admission. However, when pneumococcal meningitis was suspected, the antibiotic treatment was changed to ceftriaxone (CTRX) and vancomycin (VCM). However, owing to difficulties in achieving sufficient serum trough levels of VCM, this treatment was again switched to linezolid (LZD). The patient recovered without complications after 16 days of CTRX and LZD treatment. This case suggests that LZD is a viable treatment option for bacterial meningitis.

Indexed as

Anti-Bacterial AgentsBacteremiaCeftriaxoneMeningitis, PneumococcalPenicillin ResistanceStreptococcus pneumoniaeVancomycinDrug Therapy, CombinationHumansInfantLinezolidMaleSerogroupTreatment OutcomeAnti-Bacterial AgentsCeftriaxoneLinezolidVancomycinlinezolidmeningitispneumococcal vaccinePRSP

Identifiers

PMID39523005
PMCPMC12223023

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.