Evidence map›Paper›PMID 39524443›Full record

ArticleFrontiers in immunology2024

Human genital dendritic cell heterogeneity confers differential rapid response to HIV-1 exposure.

Siddharth Parthasarathy, Laura Moreno de Lara, Francisco J Carrillo-Salinas, Alexandra Werner, Anna Borchers, Vidya Iyer, Alison Vogell, Jared M Fortier, Charles R Wira, Marta Rodriguez-Garcia

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Novel Approaches for Investigating Host Responses to HIV Infection in Ex Vivo Human Genital Tissues.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  3. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siddharth ParthasarathyDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Laura Moreno de LaraDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Francisco J Carrillo-SalinasDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Alexandra WernerDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Anna BorchersDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Vidya IyerDepartment of Gynecology and Obstetrics, Tufts Medical Center, Boston, MA, United States.
Alison VogellDepartment of Gynecology and Obstetrics, Tufts Medical Center, Boston, MA, United States.
Jared M FortierC.S Mott Center for Human Growth and Development, Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, United States.
Charles R WiraDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Marta Rodriguez-GarciaDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Impact of Aging on Mucosal Immune Protection in the Female ReproductiveR01AG064794 · NIA · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2019 to 2023
$2.8M
Aging Compromises Neutrophil-Mediated Innate Protection Against HIV in the Human Female Genital TractR01AG060801 · NIA · WAYNE STATE UNIVERSITY · PI RODRIGUEZ GARCIA, MARTA · 2018 to 2022
$2.6M
Spectral Cell SorterS10OD032201 · OD · TUFTS UNIVERSITY BOSTON · PI TAI, ALBERT K · 2022 to 2022
$672k
Identification of Protective Innate Immune Memory Responses Against HIV Acquisition in the Human Female Genital TractR21AI172065 · NIAID · WAYNE STATE UNIVERSITY · PI RODRIGUEZ GARCIA, MARTA · 2022 to 2023
$454k
NCI NIH HHS P30 CA023108NIAID NIH HHS R21 AI172065NIA NIH HHS R01 AG060801NIA NIH HHS R01 AG064794NIH HHS S10 OD032201
6 · The paper itself

Abstract

Dendritic cells (DCs) play critical roles in HIV pathogenesis and require further investigation in the female genital tract, a main portal of entry for HIV infection. Here we characterized genital DC populations at the single cell level and how DC subsets respond to HIV immediately following exposure. We found that the genital CD11c

Indexed as

Dendritic CellsHIV-1HIV InfectionsAdultAntigens, CD1FemaleGenitalia, FemaleGlycoproteinsHLA-DR AntigensHumansLipopolysaccharide ReceptorsMonocytesAntigens, CD1CD14 protein, humanCD1C protein, humanGlycoproteinsHLA-DR AntigensLipopolysaccharide Receptorsantiviral responsedendritic cellfemale genital tractHIVmucosal immunitysingle-cell RNA sequencing

Identifiers

PMID39524443
PMCPMC11543421

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.