Evidence map›Paper›PMID 39527393›Full record

ReviewCurrent reviews in musculoskeletal medicine2024

Advanced Non-Operative Interventions for Anterior Knee Pain.

Nicole B Katz, Nicholas Tsitsilianos, Andrew S Nowak, Stephanie R Douglas, Adam S Tenforde, Joanne Borg-Stein

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current reviews in musculoskeletal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07255248 (Hoffa's Fat Pad Impingement), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07255248 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Hoffa's Fat Pad Impingement (HFPI): Saline Injection Verus Ultrasound Guided Cortisone Injection: A Randomized Trial in Adolescent Female Athletes

TypeinterventionalSponsorBoston Children's HospitalRan2026 to 2028Enrolled62ConditionsHoffa's Fat Pad ImpingementArmsmethylprednisolone acetate and lidocaine, Saline injection (Octreotide LAR placebo)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicole B KatzDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA. NKatz@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-8707-5034
Nicholas TsitsilianosDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
Andrew S NowakCentral Michigan University College of Medicine, Mount Pleasant, MI, 48858, USA.
Stephanie R DouglasDepartment of Orthopedics, Division of Physical Medicine and Rehabilitation, University in St. Louis, St. Louis, MO, 63110, USA.
Adam S Tenforde *Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
Joanne Borg-Stein *Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review presents evidence for advanced non-operative interventions, including extracorporeal shockwave therapy (ESWT), prolotherapy, platelet-rich plasma (PRP), adipose tissue-derived cells, bone marrow aspirate concentrate, various additional non-corticosteroid injectates, and needle-based interventions for common causes of anterior knee pain in the adult population. These etiologies include osteoarthritis of the knee, patellofemoral pain syndrome, chondromalacia patella, Hoffa fat pad impingement syndrome, patellar/quadriceps tendinopathy, and prepatellar bursitis. This review discusses patient care options using a case-based understanding of interventions by condition while recognizing strength of evidence. RECENT

findingsESWT and PRP are the most robustly studied and have greatest evidence for treating tibiofemoral osteoarthritis and for long-term benefit in treating patellar tendinopathy. PRP may have evidence for treatment of chondromalacia and prolotherapy for management of tibiofemoral arthritis; both have limited evidence. Botulinum neurotoxin type A has strong evidence to support use in treating patellofemoral pain syndrome. There is limited evidence to support the use of viscosupplementation, percutaneous needle tenotomy, and medicinal signaling cell-based therapies beyond platelet-rich plasma for anterior knee pain. There is limited research on the management of quadriceps tendinopathy, prepatellar bursitis, patellofemoral osteoarthritis, and Hoffa's fat pad impingement syndrome. Further research and standardization of protocols are necessary to fully assess these treatments' efficacy. ESWT, cell-based, and needle-based interventions, may serve as effective treatment options for patients with anterior knee pain. Selection of each intervention requires understanding the evidence, level of risk, and appropriate application based on a patient's level of activity to enable clinicians to enhance patient outcomes and quality of life.

Indexed as

Hoffa SyndromeKnee osteoarthritisKnee painPatellar tendinopathyPatellofemoral pain syndromePrepatellar bursitis

Identifiers

PMID39527393
PMCPMC11652466

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.