ArticleBMC psychiatry2024
Estimated glucose disposal rate is correlated with increased depression: a population-based study.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Estimated glucose disposal rate is correlated with decreased parkinson's disease: a population-based study.Acta neurologica Belgica · 2026Article
- The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Cardiometabolic Index as a Mediator in the Association Between Estimated Glucose Disposal Rate and Depressive Symptoms: A Population-Based Study.Brain and behavior · 2026Article
- Association between estimated glucose disposal rate and testosterone deficiency in male patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Association between dietary niacin intake and suicidal ideation: mediating role of C-reactive protein.BMC psychiatry · 2025Article
- Assessing the Impact of Estimated Glucose Disposal Rate (eGDR) on Cognitive Function in Older Adults: A NHANES-Based Machine Learning Study.CNS neuroscience & therapeutics · 2025Article
- Association of omega-3, omega-6 fatty acids intakes and omega-6: omega-3 ratio with the prevalence of suicidal ideation: mediating role of C-reactive protein.Lipids in health and disease · 2025Article
- Inflammatory burden index is correlated with increased depression: a population-based study.BMC psychiatry · 2025Article
- Correlation between estimated glucose disposal rate, insulin resistance, and cardiovascular mortality among individuals with metabolic syndrome: a population-based analysis, evidence from NHANES 1999-2018.Diabetology & metabolic syndrome · 2025Article
- Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma.Frontiers in psychiatry · 2025Article
- Dietary live microbe intake and its association with Parkinson's disease in American adults: an NHANES analysis (1999-2018).Frontiers in nutrition · 2025Article
- Correlation between estimated glucose disposal rate and diabetic depression: a population-based study.Frontiers in psychiatry · 2025Article
- Association between estimated glucose disposal rate and metabolic syndrome: a cross-sectional analysis of the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have identified a correlation between insulin resistance (IR) and depression. This study aims to explore the correlation between estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and depression in the general population.
methodsIn this population-based cross-sectional study, data from 28,444 adults aged 18 years old or older in the NHANES during the period from 1999 to 2018 were analyzed. The correlation between eGDR and depression was examined through multivariate logistic regression analyses, subgroup analyses, restricted cubic spline, and interaction tests. Furthermore, a mediation analysis was conducted to elucidate the role of the atherogenic index of plasma (AIP) in mediating the effect of eGDR on depression.
resultsMultivariate logistic regression analysis and restricted cubic splines analysis indicated that eGDR can exhibit a linearly correlation with depression (OR = 0.913; 95% CI: 0.875, 0.953). Subjects in eGDR6-8 and eGDR > 8 groups had a decrease risk of depression as 25.4% and 41.5% than those in the eGDR < 4 group. This negative correlation was more pronounced in those with obesity. Mediation analysis indicated that AIP mediated 9.6% of the correlation between eGDR and depression.
conclusionseGDR was linear negatively correlated with depression, with AIP playing a mediating role. This study provides a novel perspective on the mechanism connecting IR to depression. Managing IR and monitoring AIP may contribute to alleviating depression.
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