ArticleRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Nuclear morphology explained through digital morphometry: differentiating nuclear features across the three histological grades in cutaneous squamous cell carcinoma.
Article in Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- HiGATE: hierarchical graph attention for multi-scale tissue encoder in computational pathology.Frontiers in oncology · 2026Article
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Authors and funding
8 authors.
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Abstract
introductionThe accurate grading of cutaneous squamous cell carcinoma (cSCC) is crucial for effective treatment and patient care, but the current method, relying on pathologist visual assessment, can be subjective.
aimThis study aimed to quantitatively investigate nuclear morphometrics in cSCC tumor cells, specifically examining potential differences between established histological grades and exploring the utility of digital morphometrics in characterizing nuclear morphology. MATERIALS AND
methodsWe analyzed 47 cSCC cases, utilizing whole slide images and CellProfiler software to extract nuclear morphometric features from a total of 519 828 nuclei.
resultsThe results showed significant differences in nuclear size, shape, and spatial arrangement between different tumor grades. Notably, grade 3 tumors exhibited distinct characteristics compared to grades 1 and 2, suggesting a potential shift towards a simplified, 2-tier grading system.
conclusionsThe study highlights the potential of digital morphometrics as a valuable tool for enhancing the accuracy and objectivity of cSCC grading, ultimately improving patient care.
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