Evidence map›Paper›PMID 39529694›Full record

ArticleFrontiers in cellular neuroscience2024

Cholecystokinin-expressing neurons of the ventromedial hypothalamic nucleus control energy homeostasis.

Vasileios Eftychidis, Tommas J Ellender, Jacek Szymanski, Liliana Minichiello

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vasileios EftychidisDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Tommas J EllenderDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Jacek SzymanskiDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Liliana MinichielloDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.

Funding

Medical Research Council MR/W005166/1
6 · The paper itself

Abstract

The hypothalamus is the primary center of the brain that regulates energy homeostasis. The ventromedial hypothalamus (VMH) plays a central role in maintaining energy balance by regulating food intake, energy expenditure, and glucose levels. However, the cellular and molecular mechanisms underlying its functions are still poorly understood. Cholecystokinin (CCK) is one of many genes expressed in this hypothalamic nucleus. Peripheral CCK regulates food intake, body weight, and glucose homeostasis. However, current research does not explain the function of CCK neurons in specific nuclei of the hypothalamus and their likely roles in network dynamics related to energy balance and food intake. This study uses genetic and pharmacological methods to examine the role of CCK-expressing neurons in the VMH (CCK

Indexed as

body weightcentral CCKenergy homeostasisfood intakeglucose homeostasishypothalamusVMH

Identifiers

PMID39529694
PMCPMC11550940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.