Weight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial.

Further weight loss during the 52 weeks of interventionlooks bad hereHigher serum 25 D.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

+14.0+6.00 to +22.0

further weight loss during the 52 weeks of intervention vs regaining weight, in women

As reported

difference 14, 95% CI 6.00–22.0

215people in the Synergy Effect of the Appetite Hormone GLP-1 trial, from 2016

195of them with obesity, in this paper

Already taking further weight loss during the 52 weeks of intervention, or nottheir own situation, not assigned

on further weight loss during the 52 weeks of intervention

regaining weight

Further weight loss during the 52 weeks of intervention went with higher serum 25 D+14.0

correlation, not a test

the abstract, start to end

… D (25(OH)D) in both women and men [12 nmol/L (95% confidence interval [CI] 9-15) and 13 nmol/L (95% CI 8-17); P < .001 …

… compared with women regaining weight [14 nmol/L (95% CI 6-22); P = …

← favours treatmentfavours comparator →

could be chance

Serum 25-hydroxyvitamin D (25(OH)D)low-calorie diet-induced weight loss, in women

129.00–15.0

Serum 25-hydroxyvitamin D (25(OH)D)low-calorie diet-induced weight loss, in men

138.00–17.0

Serum 25(OH)Dfurther weight loss during the 52 weeks of intervention vs regaining weight, in women

146.00–22.0

Supplements & botanicalsDiet, exercise & lifestyleBody weight & compositionInflammation & biomarkers

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2024

2025

2026

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