Evidence map›Paper›PMID 39531032›Full record

ArticleACS synthetic biology2024

Optogenetic Control of Phosphate-Responsive Genes Using Single-Component Fusion Proteins in

Matthew M Cleere, Kevin H Gardner

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Structural Basis of a Novel Heme Binding Bacterial One-Component Switch.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Matthew M CleereStructural Biology Initiative, CUNY Advanced Science Research Center, New York, New York 10031, United States.
Kevin H GardnerStructural Biology Initiative, CUNY Advanced Science Research Center, New York, New York 10031, United States.ORCID 0000-0002-8671-2556

Funding

Summer Undergraduate Research Support - Ms. Anastasiia FisiukR01GM106239 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GARDNER, KEVIN H · 2013 to 2024
$4.5M
NIGMS NIH HHS R01 GM106239
6 · The paper itself

Abstract

Blue light illumination can be detected by light-oxygen-voltage (LOV) photosensing proteins and translated into a range of biochemical responses, facilitating the generation of novel optogenetic tools to control cellular function. Here, we develop new variants of our previously described VP-EL222 light-dependent transcription factor and apply them to study the phosphate-responsive signaling (

Indexed as

OptogeneticsPhosphatesPromoter Regions, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAcid PhosphataseDNA-Binding ProteinsGene Expression Regulation, FungalLightPlasmidsProton-Phosphate SymportersRecombinant Fusion ProteinsSignal TransductionTranscription FactorsAcid PhosphataseDNA-Binding ProteinsPHO4 protein, S cerevisiaePHO5 protein, S cerevisiaePHO84 protein, S cerevisiaePhosphatesProton-Phosphate SymportersRecombinant Fusion ProteinsSaccharomyces cerevisiae ProteinsTranscription FactorschromatinEL222inorganic phosphate (Pi)LOV domainoptogeneticstranscriptionyeast

Identifiers

PMID39531032
PMCPMC12089998

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.