Evidence map›Paper›PMID 39531048›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2025

Effects of iron overload in human joint tissue explant cultures and animal models.

Indira Prasadam, Karsten Schrobback, Bastian Kranz-Rudolph, Nadine Fischer, Yogita Sonar, Antonia RuJia Sun, Eriza Secondes, Travis Klein, Ross Crawford, V Nathan Subramaniam and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Trace Elements-Role in Joint Function and Impact on Joint Diseases.International journal of molecular sciences · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Indira Prasadam *Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia. i.prasadam@qut.edu.au.ORCID http://orcid.org/0000-0001-5057-2427
Karsten Schrobback *Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Bastian Kranz-RudolphCentre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Nadine FischerCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Yogita SonarCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Antonia RuJia SunCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Eriza SecondesHepatogenomics Research Group, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD, 4059, Australia.
Travis KleinCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Ross CrawfordCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
V Nathan SubramaniamHepatogenomics Research Group, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Qld, 4059, Australia.
Gautam RishiHepatogenomics Research Group, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Qld, 4059, Australia.

Funding

National Health and Medical Research Council GNT1082224National Health and Medical Research Council GNT1118888National Health and Medical Research Council GNT1176298
6 · The paper itself

Abstract

Osteoarthritis (OA) is a prevalent degenerative joint disease affecting over 530 million individuals worldwide. Recent studies suggest a potential link between iron overload, a condition characterised by the excessive accumulation of iron in the body, and the onset of OA. Iron is essential for various biological processes, and any disruption in its homeostasis can trigger significant health effects, including OA. This study aimed to elucidate the effects of excess iron on joint tissue and the underlying mechanisms associated with excess iron and OA development. Human articular cartilage (n = 6) and synovium (n = 4) were collected from patients who underwent total knee arthroplasty. Cartilage and synovium explants were incubated with a gradually increasing concentration of ferric ammonium citrate for 3 days respectively. The effects of iron homeostasis in tissue explants were analysed using a Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). To further study the effects of iron excess on OA initiation and development, male 3-week-old Hfe

Indexed as

Cartilage, ArticularIron OverloadOsteoarthritisSynovial MembraneAnimalsDisease Models, AnimalHemochromatosisHemochromatosis ProteinHumansIronMaleMiceMice, KnockoutHemochromatosis ProteinIronHaemochromatosisHFEIron overloadOsteoarthritisTransferrin receptor 2

Identifiers

PMID39531048

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.