Evidence map›Paper›PMID 39532232›Full record

ArticleJournal of the American Academy of Dermatology2025

A diverse hidradenitis suppurativa cohort: A retrospective cross-sectional study of 13,130 patients from a large US health care system database from 1995 to 2022.

Kelly Z Young, Ian Loveless, Wan-Ting K Su, Jesse Veenstra, Congcong Yin, Peter Dimitrion, Rachel Krevh, Li Zhou, Ruicong She, Mingming Pan and 12 more

Abstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kelly Z YoungCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Ian LovelessCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan.
Wan-Ting K SuCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan.
Jesse VeenstraCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Congcong YinCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan.
Peter DimitrionCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan; Cancer Biology Graduate Program, School of Medicine, Wayne State University, Detroit, Michigan.
Rachel KrevhCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan.
Li ZhouCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan; Department of Biochemistry, Microbiology, and Immunology, School of Medicine, Wayne State University, Detroit, Michigan; Department of Internal Medicine, Henry Ford Health, Detroit, Michigan.
Ruicong SheCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan.
Mingming PanCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan.
Albert M LevinCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan.
Albert YoungDepartment of Dermatology, Henry Ford Health, Detroit, Michigan.
Eglal SamirCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Andrea DaiCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan.
James GeCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Richard H HugginsHenry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Cristina de Guzman StrongCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Henry W LimHenry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan.
David M OzogHenry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan.
Iltefat HamzaviDepartment of Dermatology, Henry Ford Health, Detroit, Michigan. Electronic address: ihamzav1@hfhs.org.
Indra AdriantoCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan. Electronic address: iadrian1@hfhs.org.
Qing-Sheng MiCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan; Henry Ford Health + Michigan State University Health Sciences, East Lansing, Michigan; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Dermatology, Henry Ford Health, Detroit, Michigan; Cancer Biology Graduate Program, School of Medicine, Wayne State University, Detroit, Michigan; Department of Biochemistry, Microbiology, and Immunology, School of Medicine, Wayne State University, Detroit, Michigan; Department of Internal Medicine, Henry Ford Health, Detroit, Michigan. Electronic address: qmi1@hfhs.org.

Funding

Using whole-exome sequencing to uncover key genetic variants related to Hidradenitis Suppurativa risk in African American and Hispanic population.R01AR078688 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON, MI, QING-SHENG · 2021 to 2025
$4.1M
Whole genome sequencing analysis of hidradenitis suppurativaR01AR083553 · NIAMS · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Indra Adrianto, QING-SHENG MI · 2024 to 2026
$2.2M
Genetic risk of hidradenitis suppurativa in African AmericansR21AR079089 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2022 to 2023
$520k
Uncover the new subsets of epidermal Langerhans cellsR33AR076803 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2021 to 2021
$380k
NIAMS NIH HHS R01 AR078688NIAMS NIH HHS R01 AR083553NIAMS NIH HHS R21 AR079089NIAMS NIH HHS R33 AR076803
6 · The paper itself

Abstract

backgroundMost epidemiological studies of hidradenitis suppurativa (HS) have described homogeneous patient populations.

objectiveTo characterize demographics, modifiable health behaviors, and comorbidities of HS patients within a diverse cohort.

methodsA retrospective cross-sectional study of 13,130 HS patients within a health care system was conducted.

resultsA female sex bias of ∼3:1 in all racial/ethnic subgroups was observed. Black/African American (AA) patients had a lower age at HS diagnosis than White patients (37.1 years vs 39.4 years, P < .001). A higher proportion of Black/AA females than White females with HS had body mass index in the obese range (69.9% vs 56.5%; P = .03). In contrast, fewer Black/AA males with HS had a body mass index in the obese range compared to White males (51.4% vs 61.0%; P < .001). More Black/AA patients than White patients with HS had congestive heart failure (odds ratio (OR) = 2.10, confidence interval (CI) = 1.19-3.78; P < .05), chronic pulmonary disease (OR = 1.34; CI = 1.02-1.78; P < .05), diabetes with chronic complication (OR = 1.73; CI = 1.16-2.60; P < .05), renal disease (OR = 2.66; CI = 1.67-4.34; P < .05), and Charlson comorbidity index score ≥4 (OR = 1.67; CI = 1.09-2.58; P < .05). Furthermore, male patients were more likely than female patients to have renal disease (OR = 2.62; CI = 1.66-4.14; P < .05). LIMITATIONS: A single-center study.

conclusionSubgroups of HS patients had significant differences in demographics, risk factors, and comorbid conditions.

Indexed as

Hidradenitis SuppurativaAdultBlack or African AmericanBody Mass IndexComorbidityCross-Sectional StudiesDatabases, FactualFemaleHumansMaleMiddle AgedObesityRetrospective StudiesSex FactorsUnited StatesWhitecomorbiditydemographicsepidemiologyhidradenitis suppurativarisk factorssex bias

Identifiers

PMID39532232
PMCPMC11859765

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.