Evidence mapPaperPMID 39532799Full record

ReviewDiscover oncology2024

Late side effects of testicular cancer and treatment: a comprehensive review.

M Raheel Khan, Patrice Kearney Sheehan, Ashley Bazin, Christine Leonard, Umair Aleem, Lynda Corrigan, Ray McDermott

Abstract readReview
In one paragraph

Review in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M Raheel KhanDepartment of Medical Oncology, Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland. mraheelhashim@hotmail.com.
Patrice Kearney SheehanDepartment of Medical Oncology, Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland.
Ashley BazinDepartment of Medical Oncology, Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland.
Christine LeonardDepartment of Medical Oncology, Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland.
Umair AleemDepartment of Medical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Withington, Manchester, M20 4BX, UK.
Lynda CorriganDepartment of Medical Oncology, Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland.
Ray McDermottDepartment of Medical Oncology, Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testicular cancer is a rare solid organ tumour associated with high cure rates and young age at diagnosis, hence it has a sizeable cohort of survivors worldwide. As it is one of the earliest tumours to be cured, a lot of studies have highlighted the late side effects of cancer and its different treatment modalities including surgery, radiotherapy and chemotherapy. While we are trying to identify the population at higher risk of platinum based chemotherapy and reduce its exposure, cisplatin based regimes remain an important tool to cure testicular cancer. The list of late side effects include a number of fatal and morbid conditions including but not limited to the second malignant neoplasms, cardiovascular disease, hypogonadism, infertility, metabolic syndrome, chronic respiratory disease, renal insufficiency, hearing loss, peripheral neuropathy, infertility and psychological illnesses like stress and anxiety. These complications eventually result in compromised social and economic health as well as lower life expectancy compared to the normal population. This article provides a comprehensive review of the latest data regarding the late side effects in testicular cancer survivors. A review of these conditions can help us develop recommendations and guidelines to improve the morbidity and mortality in survivors of testicular cancer.

Indexed as

Cancer survivorshipChemotherapy late side-effectGerm cell tumoursTesticular cancer

Identifiers

PMID39532799
PMCPMC11557811

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.